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Ethosuximide

Catalog No. T0728 CAS 77-67-8

Synonyms: Zarontin

Ethosuximide (Zarontin) is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other types of seizures.

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Ethosuximide, CAS 77-67-8

Pack Size	Availability	Price/USD
200 mg	In stock	$ 35.00
500 mg	In stock	$ 53.00
1 mL * 10 mM (in DMSO)	In stock	$ 57.00

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Purity: 99.72%

Purity: 98.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ethosuximide (Zarontin) is an anticonvulsant, blocks the low voltage-activated T-type calcium channel used in the treatment of absence seizures unaccompanied by other types of seizures.
In vitro	Ethosuximide(ETH) enhances hippocampal derived NSC proliferation and neurospheres formation in vitro. Low concentration of ETH induces proliferation of NSC, while higher concentrations of ETH are cytotoxic. Also, ETH activates the PI3K/Akt signal transduction pathway in adult hippocampal NSC in vitro. Blockade of the PI3K/Akt pathway inhibits ETH induced hippocampal NSC neuronal differentiation[3].
In vivo	Anti-epileptic drug ethosuximide rescues the short lifespan and chemosensory defects exhibited by C. elegans null mutants of dnj-14, the worm orthologue of the DNAJC5 gene mutated in autosomal-dominant adult-onset neuronal ceroid lipofuscinosis. It also ameliorates the locomotion impairment and short lifespan of worms expressing a human Tau mutant that causes frontotemporal dementia[1]. Ethosuximide extends lifespan by inhibiting the function of specific chemosensory neurons[2]. It increases neurogenesis, reduces neurodegeneration, and reverses cognitive impairments in rat model of AD like phenotypes[3].
Cell Research	Mouse Neuro2A (N2A) neuroblastoma cells are cultured on 6-well plates and treated with retinoic acid to induce neuronal differentiation. After 24 h, N2A cells are treated with vehicle control (PBS) or increasing concentrations of ethosuximide for 5 h. Total RNA is then isolated, DNase-treated and reverse transcribed to cDNA. qRT-PCR is run above normalising to the reference genes glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and β-actin (ACTB). (Only for Reference)

Synonyms	Zarontin
Molecular Weight	141.17
Formula	C7H11NO2
CAS No.	77-67-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 198.3 mM

DMSO: 198.3 mM

References and Literature

1. Chen X, et al. Mol Neurodegener. 2015, 10:51. 2. Collins JJ, et al. PLoS Genet. 2008, 4(10):e120200230. 3. Tiwari SK, et al. J Biol Chem. 2015, 290(47):28540-28558. 4. Coulter DA, et al. Ann Neurol. 1989, 25(6):582-93.

Citations

1. Wang X, Luo J, Wen Z, et al. Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung. PLoS pathogens. 2022, 18(2): e1010343.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Tobacco Monomer Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Membrane Protein-targeted Compound Library Clinical Compound Library Pediatric Drug Library Bioactive Compound Library Calcium Channel Compound Library

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Keywords

Ethosuximide 77-67-8 Membrane transporter/Ion channel Metabolism Calcium Channel Inhibitor Ca channels inhibit Zarontin Ca2+ channels inhibitor

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