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FPS-ZM1

Catalog No. T3259 CAS 945714-67-0

FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.

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FPS-ZM1, CAS 945714-67-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 43.00
10 mg	In stock	$ 52.00
25 mg	In stock	$ 93.00
50 mg	In stock	$ 150.00
100 mg	In stock	$ 231.00
200 mg	In stock	$ 369.00
500 mg	In stock	$ 622.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.3%

Purity: 98.39%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	FPS-ZM1 is a high-affinity RAGE specific inhibitor that blocks Aβ binding to the V domain of RAGE.
Targets&IC50	RAGE:25 nM. (Ki)
In vitro	FPS-ZM1 blocks Aβ binding to the V domain of RAGE and inhibited Aβ40- and Aβ42-induced cellular stress in RAGE-expressing cells in vitro. It blocks binding of other ligands to RAGE as well, such as S100B, AGE, and HMGB1, which have been suggested to contribute to RAGE-mediated long-term tissue damage in models of diabetes, immune/inflammatory disorders, and AD[1].
In vivo	FPS-ZM1 is nontoxic to mice and readily crossed the blood-brain barrier (BBB).It effectively controls progression of an Aβ-mediated brain disorder and the related neurovascular and cognitive dysfunction in 17-month-old APPsw/0 mice with fully developed Aβ and amyloid pathology by blocking RAGE actions at the BBB and in brain. Also, FPS-ZM1 blocks RAGE-dependent BACE1 expression and activity in brain of 17-month-old APPsw/0 mice[1].
Kinase Assay	Human sRAGE is immobilized (10 μg/mL) overnight at 4°C in 96-well microtiter plates and blocked with 3% bovine serum albumin. 125I-labeled Aβ40, HMGB1, or S100B at 5 nM in the absence and presence of various concentrations of FPS2 or FPS-ZM1 (10 to 1,000 nM) is added to the wells containing immobilized sRAGE and incubated for 1 hour at room temperature in PBS. Wells are washed with cold PBS to remove unbound radiolabeled ligands, and the radioactivity is analyzed[1].
Cell Research	CHO cells are treated for 72 hours with different concentrations of inhibitors ranging from 10 nM to 10 μM. The cellular toxicity was determined using the WST-8 Assay Kit. (Only for Reference)

Molecular Weight	327.85
Formula	C20H22ClNO
CAS No.	945714-67-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 198.3 mM

References and Literature

1. Deane R, et al. J Clin Invest. 2012, 122(4):1377-1392. 2. He C, Sun S, Zhang Y, et al. The role of irreversible electroporation in promoting M1 macrophage polarization via regulating the HMGB1-RAGE-MAPK axis in pancreatic cancer[J]. OncoImmunology. 2021, 10(1): 1897295.

Citations

1. He C, Sun S, Zhang Y, et al. The role of irreversible electroporation in promoting M1 macrophage polarization via regulating the HMGB1-RAGE-MAPK axis in pancreatic cancer. OncoImmunology. 2021 Mar 11;10(1):1897295. doi: 10.1080/2162402X.2021.1897295.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Neurodegenerative Disease Compound Library Bioactive Compounds Library Max Stem Cell Differentiation Compound Library NO PAINS Compound Library Neuronal Signaling Compound Library CNS-Penetrant Compound Library Target-Focused Phenotypic Screening Library Anti-Alzheimer's Disease Compound Library Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

FPS-ZM1 945714-67-0 Neuroscience Others Beta Amyloid advanced glycation end products β-amyloid peptide Amyloid-β Inhibitor inhibit FPS-ZM-1 FPS ZM1 FPSZM1 Abeta inhibitor

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