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Farampator

Catalog No. T3957 CAS 211735-76-1

Synonyms: Org24448, CX-691

Farampator (CX-691) (CX-691;Org24448) is a positive modulator of AMPA receptor.

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Farampator, CAS 211735-76-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 37.00
2 mg	In stock	$ 50.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 238.00
50 mg	In stock	$ 413.00
100 mg	In stock	$ 615.00
500 mg	In stock	$ 1,320.00
1 mL * 10 mM (in DMSO)	In stock	$ 88.00

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Purity: 99.83%

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Description	Farampator (CX-691) (CX-691;Org24448) is a positive modulator of AMPA receptor.
In vitro	CX691 attenuates a scopolamine-induced impairment of cued fear conditioning following acute administration (0.1 mg/kg p.o.) and a temporally induced deficit in novel object recognition following both acute (0.1 and 1.0 mg/kg p.o.) and sub-chronic (bi-daily for 7 days) administration (0.01, 0.03, 0.1 mg/kg p.o.). It also improves attentional set-shifting following sub-chronic administration (0.3 mg/kg p.o.). Farampator (500 mg) unequivocally improves short-term memory but appeares to impair episodic memory. Furthermore, it tends to decrease the number of switching errors in the CTMT. Drug-induced side effects (SEs) included headache, somnolence and nausea. Subjects with SEs has significantly higher plasma levels of farampator than subjects without SEs. Farampator has potential in treating disorders characterised by cognitive deficits such as Alzheimer's disease and schizophrenia.
In vivo	Farampator holds promise for managing cognitive deficits associated with conditions like Alzheimer's disease and schizophrenia. It mitigates scopolamine-induced cued fear conditioning impairment with a single dose (0.1 mg/kg p.o.) and rectifies deficits in novel object recognition after both acute (0.1 and 1.0 mg/kg p.o.) and sub-chronic (twice daily for 7 days at doses of 0.01, 0.03, 0.1 mg/kg p.o.) administrations. Moreover, farampator enhances attentional set-shifting with sub-chronic use (0.3 mg/kg p.o.)[1]. Notably, at a 500 mg dosage, farampator consistently improves short-term memory, albeit with a tendency to impair episodic memory and reduces switching errors in the CTMT. Reported side effects (SEs) include headache, somnolence, and nausea, with subjects exhibiting SEs displaying significantly higher plasma levels of farampator compared to those without SEs[2].

Synonyms	Org24448, CX-691
Molecular Weight	231.25
Formula	C12H13N3O2
CAS No.	211735-76-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (216.21 mM)

References and Literature

1. Woolley ML, et al. Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat. Psychopharmacology (Berl). 2009 Jan;202(1-3):343-54. 2. Wezenberg E, et al. Acute effects of the ampakine farampator on memory and information processing in healthy elderly volunteers. Neuropsychopharmacology. 2007 Jun;32(6):1272-83.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Alzheimer's Disease Compound Library Clinical Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library NO PAINS Compound Library Bioactive Compound Library

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Keywords

Farampator 211735-76-1 Membrane transporter/Ion channel Neuroscience GluR iGluR inhibit Org 24448 Org-24448 Org24448 Inhibitor CX 691 CX691 Ionotropic glutamate receptors CX-691 inhibitor

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