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Fuscoside
Fuscoside (OPC-21268) is a non-peptide arginine vasopressin (AVP) receptor VI antagonist with an IC50 value of 0.4 μM[2].
Catalog No. T4355Cas No. 131631-89-5
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Purity:99.66%
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Fuscoside
Catalog No. T4355Alias OPC 21268Cas No. 131631-89-5
Fuscoside (OPC-21268) is a non-peptide arginine vasopressin (AVP) receptor VI antagonist with an IC50 value of 0.4 μM[2].
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $52 | In Stock | |
| 5 mg | $80 | In Stock | |
| 10 mg | $108 | In Stock | |
| 25 mg | $182 | In Stock | |
| 50 mg | $256 | In Stock | |
| 100 mg | $442 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $80 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Fuscoside (OPC-21268) is a non-peptide arginine vasopressin (AVP) receptor VI antagonist with an IC50 value of 0.4 μM[2]. |
| Targets&IC50 | V1 (human):8800 nM, V1 (rat):25 nM |
| In vitro | Fuscoside (OPC-21268) can replace 50% of the specific AVP binding concentration (IC50), including 0.4 μM for VI receptors and 100 μM for V2 receptors; at the same time, the inhibition constant (Ki) of Fuscoside (OPC-21268) for V1 receptors is 0.14 μM[2]. |
| In vivo | METHODS: OPC-21268 was injected intravenously into dogs and rats at doses of 0.3, 1.0, and 3.0 mg/kg to study its antagonistic effects on arginine vasopressin (AVP)-induced vasoconstrictor responses in spinally anesthetized dogs. RESULTS OPC-21268 produced a right-parallel shift of the AVP dose-response curve in a dose-dependent manner; doses of OPC-21268 were similar to those that inhibited AVP-induced vasoconstrictor responses in rats; OPC-21268 acted as a V1-AVP receptor antagonist in peripheral resistance vessels of dogs and rats. [1] |
| Alias | OPC 21268 |
| Molecular Weight | 449.54 |
| Formula | C26H31N3O4 |
| Cas No. | 131631-89-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/mL (133.47 mM), Sonication is recommended.  Ethanol: 11.24 mg/mL (25 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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