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FzM1
FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT/β-catenin signaling pathway.
Catalog No. T24076Cas No. 1680196-54-6
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Purity:99.89%
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FzM1
Catalog No. T24076Alias FzM-1, FzM 1Cas No. 1680196-54-6
FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT/β-catenin signaling pathway.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $35 | In Stock | |
| 10 mg | $58 | In Stock | |
| 25 mg | $119 | In Stock | |
| 50 mg | $198 | In Stock | |
| 100 mg | $333 | In Stock | |
| 200 mg | $472 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $34 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT/β-catenin signaling pathway. |
| In vitro | FzM1 inhibited Gli activity less efficiently than TCF/LEF activity (log EC50 of −4.6 and −5.7, respectively). On the contrary, it did not modulate CRE activity (log EC50 > −4.0), indicating that it does not influence GPCRs linked to G proteins[2]. |
| Alias | FzM-1, FzM 1 |
| Molecular Weight | 360.43 |
| Formula | C21H16N2O2S |
| Cas No. | 1680196-54-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 65 mg/mL (180.34 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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