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By Target- Wnt/beta-catenin
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Results for "
fzm1
" in TargetMol Product Catalog- Inhibitors & Agonists2
FzM1
FzM 1,FzM-1
T240761680196-54-6In house
FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2) by binding to an allosteric site on intracellular loop 3 (ICL3) of FZD4. This interaction changes the receptor's conformation and inhibits the WNT/β-catenin signaling pathway.
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FzM1.8
T153632204290-85-5
FzM1.8 is an allosteric FZD4 agonist with a pEC50 of 6.4. FzM1.8 binds to FZD4, promotes TCF/LEF transcriptional activity in the absence of any WNT ligand, and activates the WNT/β-catenin pathway.
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