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GANT 58

Catalog No. T15370 CAS 64048-12-0

Synonyms: NSC 75503

GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).

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GANT 58, CAS 64048-12-0

Pack Size	Availability	Price/USD
2 mg	In stock	$ 32.00
5 mg	In stock	$ 48.00
10 mg	In stock	$ 76.00
25 mg	In stock	$ 167.00
50 mg	In stock	$ 265.00
100 mg	In stock	$ 425.00
1 mL * 10 mM (in DMSO)	In stock	$ 59.00

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Purity: 99.88%

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Description	GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).
Targets&IC50	GLI:5 μM
In vitro	GANT58 is a downstream inhibitor of Hh signaling and it also is an indeed inhibitor of Hh signaling downstream of Smo and Sufu. GANT58 potently inhibits in vitro tumor cell proliferation in a GLI-dependent manner and successfully blocks cell growth using human prostate cancer cells harboring downstream activation of the Hh pathway[1]. GANT58 has been shown to inhibit transcriptional activation by GLI1 (as well as by the other GLI species) and it has been shown to inhibit GLI transactivation[2]. GANT58 mainly acts at the nuclear level because transcription induced by GLI1 with a mutated nuclear export signal is still blocked.
In vivo	Nude mice are treated with every second-day s.c. injections at a concentration of 50 mg/kg of cyclopamine, GANT61, GANT58, or solvent only (n=4-5 for each group). Although mice treated with these compounds showed no such signs of toxicity, this protocol is also introduced for the GANTs to be able to compare all compounds. All injections are done 2-3 cm away from the tumors. Suppression of tumor cell growth is observed for all compounds, during an 18-day treatment period. Treatment with cyclopamine or GANT58 results in the inhibition of additional xenograft growth and limited the increase in tumor size[1].

Synonyms	NSC 75503
Molecular Weight	392.48
Formula	C24H16N4S
CAS No.	64048-12-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9.09 mg/mL (23.16 mM), Sonication is recommended.

References and Literature

1. Lauth M, et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A. 2007 May 15;104(20):8455-60. 2. Joo J, et al. GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS One. 2009 Oct 27;4(10):e7608.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Membrane Protein-targeted Compound Library Inhibitor Library Stem Cell Differentiation Compound Library Anti-Prostate Cancer Compound Library Bioactive Compounds Library Max Wnt/Hedgehog/Notch Compound Library Bioactive Compound Library Reprogramming Compound Library Osteogenesis Compound Library

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Related compounds with same targets

GSA-10 Ciliobrevin A Purmorphamine Naftifine hydrochloride Ellagic acid Tolnaftate HhAntag TAK-441

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Keywords

GANT 58 64048-12-0 GPCR/G Protein Stem Cells Hedgehog/Smoothened inhibit Inhibitor GANT58 GANT-58 Gli NSC75503 NSC-75503 NSC 75503 inhibitor

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