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GDC0084

Catalog No. T3705 CAS 1382979-44-3

Synonyms: GDC-0084, RG7666, GDC 0084

GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity. GDC0084 (RG7666) specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in the inhibition of both cell growth and survival in susceptible tumor cell populations.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

GDC0084, CAS 1382979-44-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 54.00
2 mg	In stock	$ 67.00
5 mg	In stock	$ 123.00
10 mg	In stock	$ 198.00
25 mg	In stock	$ 406.00
50 mg	In stock	$ 528.00
100 mg	In stock	$ 763.00
500 mg	In stock	$ 1,590.00
1 mL * 10 mM (in DMSO)	In stock	$ 123.00

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Purity: 99.16%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity. GDC0084 (RG7666) specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) signaling pathway, thereby inhibiting the activation of the PI3K signaling pathway. This may result in the inhibition of both cell growth and survival in susceptible tumor cell populations.
Targets&IC50	mTOR:70 nM(Ki app), PI3Kγ:10 nM(Ki app), PI3Kα:2 nM(Ki app), PI3Kβ:46 nM(Ki app), PI3Kδ:3 nM(Ki app)
Cell Research	For transport studies, cells are seeded on 24-well Millicell plates 4 days prior to use(polyethylene terephtalate membrane, 1 μm pore size) at a seeding density of 1.3×105 cells/ml). GDC-0084 is tested at 5 μM in the apical-tobasolateral (A-B) and basolateral-to-apical (B-A) directions. The compound is dissolved in transport buffer consisting of Hanks' balanced salt solution with 10 mM HEPES. Lucifer Yellow is used as the paracellular and monolayer integrity marker. GDC-0084 concentrations in the donor and receiving compartments are determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. The apparent permeability (Papp), in the apical to A-B and B-A directions, is calculated after 2-hour incubation.(Only for Reference)

Synonyms	GDC-0084, RG7666, GDC 0084
Molecular Weight	382.42
Formula	C18H22N8O2
CAS No.	1382979-44-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 8 mg/mL (20.91 mM)

References and Literature

1. Heffron TP, et al. ACS Med Chem Lett. 2016, 7(4):351-6. 2. Salphati L, et al. Drug Metab Dispos. 2016, 44(12):1881-1889.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Bioactive Compound Library Reprogramming Compound Library Neuronal Differentiation Compound Library

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Keywords

GDC0084 1382979-44-3 PI3K/Akt/mTOR signaling PI3K mTOR GDC-0084 RG7666 GDC 0084 RG-7666 RG 7666 inhibitor inhibit

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