Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 32.00 | |
2 mg | In stock | $ 45.00 | |
5 mg | In stock | $ 72.00 | |
10 mg | In stock | $ 122.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 556.00 | |
500 mg | In stock | $ 1,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 78.00 |
Description | GSK-872 (GSK2399872A) is an effective and specific RIP3 kinase inhibitor. It binds RIP3 kinase domain with high affinity (IC50: 1.8 nM) and inhibits kinase activity (IC50: 1.3 nM). |
Targets&IC50 | RIP3K:1.8 nM |
In vitro | GSK872 (1 μM) has no inhibition for most of 300 human protein kinases tested. It fails to inhibit RIP1 kinase. In HT-29 cells, GSK872 concentration-dependently blocks TNF-induced necroptosis. In cell-based assays, there is a 100- to 1000-fold shift in the IC50 compared to the cell-free biochemical assays. GSK872 inhibits DAI- or TLR3-induced (RIP1-independent) death. It induces caspase activation and then induces apoptotic cell death[1]. |
In vivo | In compared with no treatment after ischemic injury in vivo, GSK872 can significantly reduce HIF-1α expression [3]. |
Synonyms | GSK872, GSK'872, GSK2399872A |
Molecular Weight | 383.49 |
Formula | C19H17N3O2S2 |
CAS No. | 1346546-69-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 71 mg/mL (185.1 mM)
Ethanol: 38 mg/mL (99.1 mM)
You can also refer to dose conversion for different animals. More
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GSK-872 1346546-69-7 Apoptosis NF-Κb RIP kinase translocation neurological HMGB1 Receptor-interacting protein kinases brain GSK872 GSK 872 cytoplasmic deficits Inhibitor GSK'872 edema inhibit RIPK GSK2399872A inhibitor