Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1; IC50: 31 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 47.00 | |
5 mg | In stock | $ 77.00 | |
10 mg | In stock | $ 122.00 | |
50 mg | In stock | $ 178.00 | |
100 mg | In stock | $ 313.00 | |
200 mg | In stock | $ 468.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 108.00 |
Description | GSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1; IC50: 31 nM). |
Targets&IC50 | GSTO1:31 nM |
In vitro | GSTO1-IN-1 inhibits the clonogenic survival of HCT116 cells at sub-micromolar concentrations. GSTO1-IN-1 also potently competes with 5-chloromethylfluorescein diacetate (CMFDA) for binding to the recombinant protein, as well as endogenous GSTO1 in the milieu of a soluble proteome. HCT116 cells treated with GSTO1-IN-1 also show a decrease in cell viability in a dose-dependent manner. |
In vivo | GSTO1-IN-1 (20-45 mg/kg) is administered as a single agent to nude mice bearing HCT116 xenografts. After 5 weeks of treatment, tumor growth is significantly inhibited in GSTO1-IN-1-treated mice compared with the vehicle-treated group (P<0.05). GSTO1-IN-1 treatment is generally well tolerated by mice up to 45 mg/kg, with no overt signs of toxicity and no significant variations in average body weights throughout the duration of the study. |
Molecular Weight | 311.18 |
Formula | C10H12Cl2N2O3S |
CAS No. | 568544-03-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 300 mg/mL (964.07 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GSTO1-IN-1 568544-03-6 Metabolism oxidation-reduction Glutathione Peroxidase GST GSTs GSTO1IN1 Glutathione transferases inhibit Inhibitor Gutathione S-transferase GSTO1 IN 1 GSTO-1-IN-1 inhibitor