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Gandotinib

Catalog No. T2638 CAS 1229236-86-5

Synonyms: VEGFR, inhibit, FGFR, LY-2784544, Janus kinase, CD135, FLT3, Cluster of differentiation antigen 135, LY 2784544, Inhibitor, Gandotinib, Fms like tyrosine kinase 3, Vascular endothelial growth factor receptor, JAK, Fibroblast growth factor receptor, LY2784544

LY2784544(Gandotinib) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3.

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Gandotinib, CAS 1229236-86-5

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	LY2784544(Gandotinib) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3.
Targets&IC50	JAK2:3 nM, JAK2V617F:0.245 nM(Ki)
Cell Research	LY2784544 is dissolved in DMSO and stored, and then diluted with appropriate medium before use[1]. Ba/F3 cells expressing JAK2V617F are placed in RPMI-1640-containing vehicle (DMSO) or LY2784544 (concentration range, 0.001-20 μM) (1×104 cells/96-well). Ba/F3 cells expressing wild-type JAK2 are treated similarly except IL-3 (2 ng/mL) is added. After a 72-hour incubation, cell proliferation is assessed by adding Cell Titer 96 Aqueous One Solution Reagent (20 μL/well). The IC50 for inhibition of cell proliferation is calculated using the GraphPad Prism 4 software[1].

Synonyms	VEGFR, inhibit, FGFR, LY-2784544, Janus kinase, CD135, FLT3, Cluster of differentiation antigen 135, LY 2784544, Inhibitor, Gandotinib, Fms like tyrosine kinase 3, Vascular endothelial growth factor receptor, JAK, Fibroblast growth factor receptor, LY2784544
Molecular Weight	469.95
Formula	C23H25ClFN7O
CAS No.	1229236-86-5

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 87 mg/mL (185.1 mM)

H2O: <1 mg/mL

Ethanol: 9 mg/mL (19.15 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Ma L, et al. 53rd ASH Annual Meeting and Exposition, 2011, Abstract 4087. 2. Ma L, et al. Blood Cancer J. 2013, 3, e109.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Autophagy Compound Library Cytokine Inhibitor Library Anti-Cardiovascular Disease Compound Library Anti-Obesity Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Immunology/Inflammation Compound Library Fluorochemical Library Drug Repurposing Compound Library

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