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Glucoraphanin

🥰Excellent
Catalog No. TQ0212Cas No. 21414-41-5

Glucoraphanin, the precursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, has antioxidant activity.

Glucoraphanin

Glucoraphanin

🥰Excellent
Purity: 98.86%
Catalog No. TQ0212Cas No. 21414-41-5
Glucoraphanin, the precursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, has antioxidant activity.
Pack SizePriceAvailabilityQuantity
1 mg$48In Stock
5 mg$117In Stock
10 mg$195In Stock
25 mg$392In Stock
50 mg$662In Stock
100 mg$943In Stock
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Purity:98.86%
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Product Introduction

Bioactivity
Description
Glucoraphanin, the precursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, has antioxidant activity.
In vivo
Glucoraphanin reduces weight gain, enhances energy expenditure, improves insulin sensitivity, and glucose tolerance in HFD-fed mice, but it does not exert these effects in Nrf2-/-. It blocks HFD-induced reduction of Ucp1 protein levels in white adipose depots of wild-type mice but not in Nrf2-/-, alleviates HFD-induced hepatic steatosis and oxidative stress, and suppresses HFD-induced proinflammatory activation of macrophages in the liver and adipose tissue [1]. Additionally, pellets containing 0.1% Glucoraphanin (GF) significantly attenuate decreased social avoidance time and sucrose preference in stressed mice [2].
Animal Research
Male C57BL/6JSlc mice are 7 weeks of age. The Nrf2 knockout (Nrf2?/?) mouse strain is used in the assay. After 1 week of acclimation, mice are fed normal chow (NC) (containing 2.2% dextrinized cornstarch, 10% kcal from fat), NC containing 0.3% glucoraphanin (NC-GR) (containing 2.2% extract powder), an HFD (containing 2.2% dextrinized cornstarch, 60% kcal from fat), or an HFD containing 0.3% glucoraphanin (HFD-GR) (containing 2.2% extract powder) for 14 weeks. Both the NC and the HFD containing cornstarch or glucoraphanin are prepared. All mice studied are maintained on a 12-h light/dark cycle at 24-26°C with free access to water and food [1].
Chemical Properties
Molecular Weight437.51
FormulaC12H23NO10S3
Cas No.21414-41-5
SmilesCS(=O)CCCC\C(S[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)=N\OS(O)(=O)=O
Relative Density.1.78 g/cm3 at 20℃
Storage & Solubility Information
Storagestore at low temperature,store under nitrogen,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 74 mg/mL (169.14 mM)
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM2.2857 mL11.4283 mL22.8566 mL114.2831 mL
5 mM0.4571 mL2.2857 mL4.5713 mL22.8566 mL
10 mM0.2286 mL1.1428 mL2.2857 mL11.4283 mL
20 mM0.1143 mL0.5714 mL1.1428 mL5.7142 mL
50 mM0.0457 mL0.2286 mL0.4571 mL2.2857 mL
100 mM0.0229 mL0.1143 mL0.2286 mL1.1428 mL

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