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Glucoraphanin, the precursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, has antioxidant activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $48 | In Stock | |
5 mg | $117 | In Stock | |
10 mg | $195 | In Stock | |
25 mg | $392 | In Stock | |
50 mg | $662 | In Stock | |
100 mg | $943 | In Stock |
Description | Glucoraphanin, the precursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, has antioxidant activity. |
In vivo | Glucoraphanin reduces weight gain, enhances energy expenditure, improves insulin sensitivity, and glucose tolerance in HFD-fed mice, but it does not exert these effects in Nrf2-/-. It blocks HFD-induced reduction of Ucp1 protein levels in white adipose depots of wild-type mice but not in Nrf2-/-, alleviates HFD-induced hepatic steatosis and oxidative stress, and suppresses HFD-induced proinflammatory activation of macrophages in the liver and adipose tissue [1]. Additionally, pellets containing 0.1% Glucoraphanin (GF) significantly attenuate decreased social avoidance time and sucrose preference in stressed mice [2]. |
Animal Research | Male C57BL/6JSlc mice are 7 weeks of age. The Nrf2 knockout (Nrf2?/?) mouse strain is used in the assay. After 1 week of acclimation, mice are fed normal chow (NC) (containing 2.2% dextrinized cornstarch, 10% kcal from fat), NC containing 0.3% glucoraphanin (NC-GR) (containing 2.2% extract powder), an HFD (containing 2.2% dextrinized cornstarch, 60% kcal from fat), or an HFD containing 0.3% glucoraphanin (HFD-GR) (containing 2.2% extract powder) for 14 weeks. Both the NC and the HFD containing cornstarch or glucoraphanin are prepared. All mice studied are maintained on a 12-h light/dark cycle at 24-26°C with free access to water and food [1]. |
Molecular Weight | 437.51 |
Formula | C12H23NO10S3 |
Cas No. | 21414-41-5 |
Smiles | CS(=O)CCCC\C(S[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)=N\OS(O)(=O)=O |
Relative Density. | 1.78 g/cm3 at 20℃ |
Storage | store at low temperature,store under nitrogen,keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 74 mg/mL (169.14 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
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