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HC-067047 is a potent and selective TRPV4 antagonist that also inhibits the endogenous TRPV4-mediated response to 4α-PDH.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
5 mg | $62 | In Stock | |
10 mg | $98 | In Stock | |
25 mg | $198 | In Stock | |
50 mg | $328 | In Stock | |
100 mg | $528 | In Stock | |
1 mL x 10 mM (in DMSO) | $62 | In Stock |
Description | HC-067047 is a potent and selective TRPV4 antagonist that also inhibits the endogenous TRPV4-mediated response to 4α-PDH. |
Targets&IC50 | TRPV4 (mouse):17 ± 3 nM, TRPV4 (rat):133 ± 25 nM, TRPV4 (human):8 ± 6 nM |
In vivo | HC-067047 caused a significant reduction of the maximal micturition pressure in rats, which might be caused by an effect on TRPV4 in smooth muscle. |
Alias | HC067047 |
Molecular Weight | 471.51 |
Formula | C26H28F3N3O2 |
Cas No. | 883031-03-6 |
Smiles | Cc1c(cc(-c2ccccc2)n1CCCN1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (53.02 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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