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Hexestrol

Catalog No. T6533   CAS 84-16-2
Synonyms: Bibenzyl, Hexanoestrol, meso-Hexestrol, Hexestrofen

Hexestrol (Hexanoestrol) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.

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Hexestrol Chemical Structure
Hexestrol, CAS 84-16-2
Pack Size Availability Price/USD Quantity
100 mg In stock $ 47.00
200 mg In stock $ 68.00
500 mg In stock $ 112.00
1 mL * 10 mM (in DMSO) In stock $ 39.00
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Purity: 99.32%
Purity: 99.2%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Hexestrol (Hexanoestrol) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively.
Targets&IC50 ERβ:0.175 nM(EC50), ERα:0.07 nM(EC50)
In vitro Hexestrol binds to ERα with EC50 of 0.07 nM and to ERβ with EC50 of 0.175 nM. [1] Hexestrol inhibits activity of AKR1B13 with IC50 of 3.2 μM. [2] Hexestrol inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM. [3] Hexestrol inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM. [4] Hexestrol inhibits 17HSD5 with IC50 of 30 μM, and inhibits TBER1 with IC50 of 0.8 μM. [5] Hexestrol reacts with DNA through the catechol quinone, thus can be a carcinogen. [6]
In vivo Hexestrol administered intraperitoneally at dose of 6 mg/kg may decrease ovulation in mice, as evident by smaller ovaries and decreased luteal bodies and oocytes. [7]
Synonyms Bibenzyl, Hexanoestrol, meso-Hexestrol, Hexestrofen
Molecular Weight 270.37
Formula C18H22O2
CAS No. 84-16-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 39 mg/mL (144.2 mM)

Ethanol: 39 mg/mL (144.2 mM)

TargetMolReferences and Literature

1. Waibel M, et al. Eur J Med Chem, 2009, 44(9), 3412-3424. 2. Endo S, et al. Chem Biol Interact, 2009, 178(1-3), 151-157. 3. Asada Y, et al. Chem Biol Interact. 2009, 178(1-3), 117-126. 4. Matsumoto K, et al. Biol Pharm Bull, 2006, 29(3), 539-542. 5. Ishikura S, et al. J Biochem, 2006, 139(6), 1053-1063.

Related compound libraries

This product is contained In the following compound libraries:
NO PAINS Compound Library Drug-Fragment Library Nuclear Receptor Compound Library Endocrinology-Hormone Compound Library Bioactive Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compounds Library Max Anti-Ovarian Cancer Compound Library ReFRAME Related Library Anti-Cancer Compound Library

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Keywords

Hexestrol 84-16-2 Endocrinology/Hormones Estrogen Receptor/ERR Estrogen/progestogen Receptor Bibenzyl estrogen Hexanoestrol meso-Hexestrol Hexestrofen inhibit nonsteroidal Inhibitor synthetic inhibitor

 

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