Powder: -20°C for 3 years | In solvent: -80°C for 1 year
IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with RAD51 multimerization, accelerating proteasome-mediated RAD51 protein degradation, inhibiting cancer cell growth, and inducing apoptosis, IBR2 has proved to be an effective compound in these aspects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 113.00 | |
25 mg | In stock | $ 227.00 | |
50 mg | In stock | $ 428.00 | |
100 mg | In stock | $ 639.00 | |
500 mg | In stock | $ 1,370.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 70.00 |
Description | IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with RAD51 multimerization, accelerating proteasome-mediated RAD51 protein degradation, inhibiting cancer cell growth, and inducing apoptosis, IBR2 has proved to be an effective compound in these aspects. |
Targets&IC50 | RAD51:14.8 µM(triple-negative human breast cancer cell line MBA-MD-468) |
In vitro | IBR2 can inhibit the growth of triple-negative human breast cancer cell line MBA-MD-468 with IC50 of 14.8 μM. IBR2 shows interesting RAD51 inhibition activities. RAD51 is rapidly degraded in IBR2-treated cancer cells, and the homologous recombination repair is impaired, subsequently leading to cell death. The IC50 values of the original IBR2 are in the range of 12-20 μM for most tested cancer cell lines[1]. |
Synonyms | Isoquinoline |
Molecular Weight | 400.49 |
Formula | C24H20N2O2S |
CAS No. | 313526-24-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (249.69 mM)
You can also refer to dose conversion for different animals. More
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IBR2 313526-24-8 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis RAD51 Apoptosis Isoquinoline IBR 2 inhibit Inhibitor IBR-2 inhibitor