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IDO5L

Catalog No. T2647 CAS 914471-09-3

Synonyms: INCB024360 analogue, INCB14943

IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

IDO5L, CAS 914471-09-3

Pack Size	Availability	Price/USD
10 mg	In stock	$ 43.00
25 mg	In stock	$ 78.00
50 mg	In stock	$ 126.00
100 mg	In stock	$ 197.00
200 mg	In stock	$ 338.00
500 mg	In stock	$ 531.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Purity: 100%

Purity: 99.75%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	IDO5L (INCB024360 analogue) is an effective IDO1 inhibitor(IC50=10 nM).
Targets&IC50	IDO1:10 nM
In vitro	In an immunologically active mouse model, INCB024360 effectively inhibited tumor growth. Similarly, in mice bearing GM-CSF-secreting B16 tumors, INCB024360 (75 mg/kg b.i.d) demonstrated dose-dependent tumor growth suppression.
In vivo	INCB024360 significantly inhibits IDO1 in HeLa cells (IC50 = 19 nM) and promotes differentiation in CD4+ T cells, CD8+ T cells, and NK cells.

Synonyms	INCB024360 analogue, INCB14943
Molecular Weight	271.64
Formula	C9H7ClFN5O2
CAS No.	914471-09-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 27.2 mg/mL (100 mM)

DMSO: 27.2 mg/mL (100 mM)

References and Literature

1. Yue EW, et al. J Med Chem. 2009, 52(23), 7364-7367. 2. Liu X, et al. Blood. 2010, 115(17), 3520-3530.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Fluorochemical Library Target-Focused Phenotypic Screening Library Metabolism Compound Library Immunology/Inflammation Compound Library Immuno-Oncology Compound Library ReFRAME Related Library NO PAINS Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

IACS-8968 PF-06840003 IDO-IN-13 IACS-8968 R-enantiomer GNF-PF-3777 β-Lapachone IDO-IN-11 IDO-IN-5

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

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Step Two: Enter the in vivo formulation

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

IDO5L 914471-09-3 Metabolism Indoleamine 2,3-Dioxygenase (IDO) IDO INCB-14943 Inhibitor inhibit INCB 14943 IDO-5L INCB024360 analogue INCB14943 inhibitor

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