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IDX184

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Purity:99.29%

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COA HNMR HPLC LCMS

IDX184

Catalog No. T27586Cas No. 1036915-08-8

IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM). IDX184 is a liver-targeted nucleotide prodrug with anti-HCV activity that inhibits HCV NS5B polymerase and can be used in combination with pegylated interferon-α2a and ribavirin for the primary treatment of chronic hepatitis C. It has been shown to inhibit HCV polymerase and nucleoside polymerase.

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Pack Size	Price	Availability
1 mg	$191	In Stock
5 mg	$480	In Stock
10 mg	$687	In Stock
25 mg	$1,080	In Stock
50 mg	$1,480	In Stock

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Product Introduction

Bioactivity

Description	IDX184 is a potent, orally active, targeted HCV polymerase inhibitor and nucleoside polymerase.IDX184 effectively inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM). IDX184 is a liver-targeted nucleotide prodrug with anti-HCV activity that inhibits HCV NS5B polymerase and can be used in combination with pegylated interferon-α2a and ribavirin for the primary treatment of chronic hepatitis C. It has been shown to inhibit HCV polymerase and nucleoside polymerase.
In vitro	IDX184, a liver-targeted prodrug of the nucleotide 2′-MeG-MP, serves as a hepatitis C virus polymerase inhibitor with liver-specific targeting.[1] IDX184 is not toxic (CC50>100μM) in any tested cell line.[2] IDX184 is a second-generation, orally bioavailable nucleotide prodrug designed to provide increased anti-HCV efficacy and safety versus the parent nucleoside. In HCV replicon testing, IDX184 is the most potent inhibitor (EC50=0.3-0.45 μM) compared to any of the 2’ or 4’ modified nucleosides (EC50=4-6 μM) and is also highly inhibitory in the JFH-1 infectious system (EC50=0.06-0.11 μM).[2]
Alias	IDX-184, IDX 184

Chemical Properties

Molecular Weight	626.62
Formula	C25H35N6O9PS
Cas No.	1036915-08-8

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (79.79 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5959 mL	7.9793 mL	15.9586 mL	79.7932 mL
5 mM	0.3192 mL	1.5959 mL	3.1917 mL	15.9586 mL
10 mM	0.1596 mL	0.7979 mL	1.5959 mL	7.9793 mL
20 mM	0.0798 mL	0.3990 mL	0.7979 mL	3.9897 mL
50 mM	0.0319 mL	0.1596 mL	0.3192 mL	1.5959 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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