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JD-5037

Catalog No. T4453   CAS 1392116-14-1
Synonyms: JD 5037

JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
JD-5037 Chemical Structure
JD-5037, CAS 1392116-14-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 37.00
2 mg In stock $ 53.00
5 mg In stock $ 87.00
10 mg In stock $ 143.00
25 mg In stock $ 259.00
50 mg In stock $ 389.00
100 mg In stock $ 579.00
1 mL * 10 mM (in DMSO) In stock $ 108.00
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Purity: 98.87%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description JD-5037 is a novel, peripherally restricted CB1R antagonist with an IC50 of 1.5 nM.
Targets&IC50 CB1R:1.5 nM
In vivo JD5037, when administered at a dosage of 3 mg/kg/day intraperitoneally (i.p.), effectively induces uniform reductions in body weight and mitigates high-fat diet (HFD)-induced hyperglycemia, hepatic injury, and steatosis in obese Magel2-null mice. Likewise, oral administration of JD5037 (3 mg/kg/day, p.o.) significantly diminishes tumor size and eliminates tumors in DEN-treated mice. Moreover, JD5037 reduces anandamide (AEA) levels in hepatocellular carcinoma (HCC) samples from mice.
Animal Research Mice: JD-5037 is formulated in vehicle (V; 1% Tween80, 4% DMSO, 95% Saline). Obese mice are treated chronically (28 d) with vehicle (V; 1% Tween80, 4% DMSO, 95% Saline), JD5037, or SLV319 at a dose of 3 mg/kg, i.p. Body weight and food intake are monitored daily. Mice are euthanized by cervical dislocation under anesthesia; the brain, hypothalamus, liver, and combined fat pads are removed, weighed, and snap-frozen, and trunk blood is collected for determining the endocrine and biochemical parameters
Synonyms JD 5037
Molecular Weight 572.51
Formula C27H27Cl2N5O3S
CAS No. 1392116-14-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (87.33 mM)

TargetMolReferences and Literature

1. Knani I,etal.Targeting the endocannabinoid/CB1 receptor system for treating obesity in Prader-Willi syndrome.Mol Metab. 2016 Oct 22;5(12):1187-1199. 2. Chorvat RJ.etal.Peripherally restricted CB1 receptor blockers.Bioorg Med Chem Lett. 2013 Sep 1;23(17):4751-60. 3. Mukhopadhyay B,etal.Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms.Hepatology. 2015 May;61(5):1615-26. 4. Tan S, Liu H, Ke B, et al. The peripheral CB1 receptor antagonist JD5037 attenuates liver fibrosis via a CB1 receptor/β‐arrestin1/Akt pathway[J]. British Journal of Pharmacology. 2020, 177(12): 2830-2847.

TargetMolCitations

1. Tan S, Liu H, Ke B, et al. The peripheral CB1 receptor antagonist JD5037 attenuates liver fibrosis via a CB1 receptor/β‐arrestin1/ Akt pathway. The peripheral CB1 receptor antagonist JD5037 attenuates liver fibrosis via a CB1 receptor/β‐arrestin1/Akt pathway. British Journal of Pharmacology. 2020, 177(12): 2830-2847 2. Li P, Lin Q, Sun S, et al. Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death & Disease. 2022, 13(9): 1-15.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Anti-Obesity Compound Library Preclinical Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library GPCR Compound Library Anti-Metabolism Disease Compound Library Neuronal Signaling Compound Library Anti-Fibrosis Compound Library Bioactive Compounds Library Max

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Keywords

JD-5037 1392116-14-1 GPCR/G Protein Cannabinoid Receptor JD5037 inhibit JD 5037 Inhibitor inhibitor

 

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