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KML29

Catalog No. T4052 CAS 1380424-42-9

Purity 98.65% Datasheet

KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effectively and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50: 2.5 nM, 2-AG; >50 μM, AEA).

KML29, CAS 1380424-42-9

Pack Size	Availability	Price/USD
5 mg	In stock	60.00
10 mg	In stock	90.00
25 mg	In stock	195.00
100 mg	In stock	690.00
1 mL * 10 mM (in DMSO)	In stock	70.00

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Purity 98.65%

HNMR LCMS COA Datasheet

Biological Description

Chemical Properties

Storage & Solubility Information

Description	KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effectively and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50: 2.5 nM, 2-AG; >50 μM, AEA).
Targets&IC50	MAGL,
In vivo	DprE1-IN-2 has efficacy in a rodent model of tuberculosis.

Appearance	solid
Molecular Weight	549.42
Formula	C24H21F6NO7
CAS No.	1380424-42-9

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Chang JW, et al. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol. 2012 May 25;19(5):579-588. 2. Ignatowska-Jankowska BM,et al. In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects. Br J Pharmacol. 2014 Mar;171(6):1392-1407.

Related Compound Libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Lipid Compound Library Fluorochemical Library Anti-Metabolism Disease Compound Library Anti-cancer Metabolism Compound Library

Related Products

Related compounds with same targets

Cravatt Reagent Cravatt Reagent PF-06795071 PF-06795071 JJKK 048 JJKK 048 MAGL-IN-1 MAGL-IN-1

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.