Powder: -20°C for 3 years
In solvent: -80°C for 2 years
KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effectively and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50: 2.5 nM, 2-AG; >50 μM, AEA).
Description | KML29 is highly selective and effective monoacylglycerol lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effectively and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50: 2.5 nM, 2-AG; >50 μM, AEA). |
Targets&IC50 | human MAGL:5.9 nM, rat MAGL:43 nM, AEA:>50 μM, 2-AG:2.5 nM, mouse MAGL:15 nM |
In vivo | DprE1-IN-2 has efficacy in a rodent model of tuberculosis. |
Molecular Weight | 549.42 |
Formula | C24H21F6NO7 |
CAS No. | 1380424-42-9 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 50 mg/mL (91 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
KML29 1380424-42-9 Metabolism Lipase LPS allodynia Monoacylglycerol lipase MAGL inhibit 2-AG Inhibitor HFIP KML 29 KML-29 inhibitor