Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM,)
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 46.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 198.00 | |
25 mg | In stock | $ 369.00 | |
50 mg | In stock | $ 549.00 | |
100 mg | In stock | $ 788.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 129.00 |
Description | KY-226 is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B)(IC50: 0.25 μM,) |
Targets&IC50 | PTP1B:0.25 μM |
In vivo | In db/db mice, the oral administration of KY-226 (10 and 30 mg/kg/day, 4 weeks) significantly reduced plasma glucose and triglyceride levels as well as hemoglobin A1c values without increasing body weight gain, while pioglitazone exerted similar effects with increases in body weight gain.?KY-226 attenuated plasma glucose elevations in the oral glucose tolerance test.?KY-226 also increased pIR and phosphorylated Akt in the liver and femoral muscle.?In high-fat diet-induced obese mice, the oral administration of KY-226 (30 and 60 mg/kg/day, 4 weeks) decreased body weight gain, food consumption, and fat volume gain with increases in phosphorylated STAT3 in the hypothalamus. |
Molecular Weight | 481.67 |
Formula | C27H31NO3S2 |
CAS No. | 1621673-53-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (51.9 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
KY-226 1621673-53-7 Metabolism Phosphatase inhibit anti-diabetic leptin ZO-1 LPS insulin KY 226 KY226 phosphorylated Akt anti-obesity PTP1B neurons Inhibitor inhibitor