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Kasugamycin hydrochloride hydrate

Catalog No. T8404   CAS 200132-83-8
Synonyms: Ksg (hydrochloride hydrate)

Kasugamycin hydrochloride hydrate (Ksg (hydrochloride hydrate))(Ksg) specifically inhibits translation initiation of canonical but not of leaderless messenger RNAs. Ksg inhibition is thought to occur by direct competition with initiator transfer RNA

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Kasugamycin hydrochloride hydrate Chemical Structure
Kasugamycin hydrochloride hydrate, CAS 200132-83-8
Pack Size Availability Price/USD Quantity
200 mg In stock $ 29.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 100%
Purity: 99.82%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Kasugamycin hydrochloride hydrate (Ksg (hydrochloride hydrate))(Ksg) specifically inhibits translation initiation of canonical but not of leaderless messenger RNAs. Ksg inhibition is thought to occur by direct competition with initiator transfer RNA
Synonyms Ksg (hydrochloride hydrate)
Molecular Weight 433.84
Formula C14H28ClN3O10
CAS No. 200132-83-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 14.33 mg/mL (33.03 mM), sonification/heating is recommended.

TargetMolReferences and Literature

1. Christian Lange , Matthias Lehr , Karolin Zerulla.Effects of Kasugamycin on the Translatome of Escherichia Coli.PLoS One. 2017 Jan 12;12(1):e0168143. 2. Schuwirth BS, et al. Structural analysis of kasugamycin inhibition of translation. Nat Struct Mol Biol. 2006 Oct;13(10):879-86. 3. Schluenzen F, et al. The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Nat Struct Mol Biol. 2006 Oct;13(10):871-8.

Related compound libraries

This product is contained In the following compound libraries:
FDA-Approved & Pharmacopeia Drug Library NO PAINS Compound Library Approved Drug Library Anti-Infection Compound Library Inhibitor Library Covalent Inhibitor Library Bioactive Compound Library Anti-Bacterial Compound Library Antibiotics Library Bioactive Compounds Library Max

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Keywords

Kasugamycin hydrochloride hydrate 200132-83-8 Microbiology/Virology Antibacterial Antibiotic hydrochloride Hydrate Ksg hydrochloride Kasugamycin hydrochloride Bacterial Ksg Inhibitor Kasugamycin hydrochloride Hydrate inhibit Ksg (hydrochloride hydrate) inhibitor

 

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