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(Rac)-LB-100

Catalog No. T2068   CAS 2061038-65-9

LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
(Rac)-LB-100 Chemical Structure
(Rac)-LB-100, CAS 2061038-65-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 59.00
2 mg In stock $ 85.00
5 mg In stock $ 133.00
10 mg In stock $ 190.00
25 mg In stock $ 328.00
50 mg In stock $ 492.00
100 mg In stock $ 717.00
500 mg In stock $ 1,490.00
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Purity: 99.77%
Purity: 99.55%
Purity: 97.11%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description LB-100, a novel Protein Phosphatase 2A (PP2A) inhibitor, sensitizes malignant meningioma cells to the therapeutic effects of radiation
In vitro LB-100, a small molecular inhibitor of protein phosphatase 2A (PP2A), has been shown to enhance T cell anti-tumor activity through activation of the mTOR signaling pathway.?Herein, Investigated if a treatment strategy consisting of a combination of LB-100 and anti-CAIX CAR-T cell therapy produced a synergistic anti-tumor effect.?LB-100 enhanced anti-CAIX CAR-T cell treatment efficacy in vitro and in vivo.LB-100 in augmenting the cytotoxic activity of anti-CAIX CAR-T cells and underscore the synergistic therapeutic potential of applying combination LB-100 and CAR-T Cell therapy to other solid tumors[1].
Kinase Assay PP2A activity assays: Cultured pancreatic cancer cells are treated with IC50 of LB-100 for each cell line or equal volume of vehicle for 2 hours, and PP2A activity assays are then performed using Ser/Thr phosphatase assay kit. Cells are lysed with an ultrasonic cell disruptor, and the PP2A concentration is measured using a Ser/Thr phosphatase assay kit according to the instructions. Assays for each cell line are performed in triplicate.
Cell Research Cytotoxicity is conducted by using a Cell Counting Kit-8. Cells are seeded in 96-well plates with a density of 3000 cells per well and are assessed after treatments following the CCK-8 protocol. Relative cytotoxicity is expressed as a percentage of speci?c controls. (Only for Reference)
Molecular Weight 268.31
Formula C13H20N2O4
CAS No. 2061038-65-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: < 1 mg/mL (insoluble or slightly soluble)

H2O: 49 mg/mL (182.6 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Cui J , H Wang, Medina R , et al. Inhibition of PP2A with LB-100 Enhances Efficacy of CAR-T Cell Therapy Against Glioblastoma[J]. Cancers, 2020, 12(1):139-. 2. D'Arcy B M , Swingle M R , Papke C M , et al. The Antitumor Drug LB-100 is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Catalytic Metals in the Active Site of PP5C[J]. Molecular Cancer Therapeutics, 2019.

TargetMolCitations

1. Yue J, Vendramin R, Liu F, et al. Targeted chemotherapy overcomes drug resistance in melanoma. Genes & Development. 2020, 34(9-10): 637-649

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library NO PAINS Compound Library Metabolism Compound Library Bioactive Compound Library Phosphatase Inhibitor Library Anti-Cancer Compound Library Inhibitor Library Drug Repurposing Compound Library

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Keywords

(Rac)-LB-100 2061038-65-9 Metabolism Phosphatase LB100 LB-100 LB 100 inhibitor inhibit

 

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