Shopping Cart
- Remove All
Your shopping cart is currently empty
LY518674
🥰Excellent
Catalog No. T15821Cas No. 425671-29-0
Alias LY-674
LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agonist (EC50: 42 nM for human PPARα).
LY518674
🥰Excellent
Purity: 98.87%
Catalog No. T15821Alias LY-674Cas No. 425671-29-0
LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agonist (EC50: 42 nM for human PPARα).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $179 | In Stock | |
| 5 mg | $378 | In Stock | |
| 10 mg | $562 | In Stock | |
| 25 mg | $892 | In Stock | |
| 50 mg | $1,220 | In Stock | |
| 100 mg | $1,650 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $418 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "LY518674"
Daidzein
Cited
Isoflavone
T1238486-66-8
Daidzein (Isoflavone) is an isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic properties.
- $45
Size
QTY
Cited2,3-Butanediol
T19094513-85-9
2,3-Butanediol, derived from the bioconversion of natural resources, holds significant potential for various industries, including chemical, cosmetics, agriculture, and pharmaceutical sectors.
- $40
Size
QTY
Naringenin Cited
S-Dihydrogenistein, Salipurol, Pelargidanon, NSC 34875, NSC 11855, Naringetol
T2838480-41-1
Naringenin (NSC-11855) is a flavanone that is considered to have a bioactive effect on human health as antioxidant, free radical scavenger, antiinflammatory, carbohydrate metabolism promoter, immunity system modulater. This substance has also been shown to repair DNA.
- $50
Size
QTY
Cited5-Aminosalicylic Acid
Cited
Mesalazine, Mesalamine, 5-ASA
T064689-57-6
5-Aminosalicylic Acid (5-ASA) is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE.
- $45
Size
QTY
CitedFenofibrate Cited
Procetofen, Lipantil, Lipanthyl
T114949562-28-9
Fenofibrate (Lipanthyl) is a PPARα agonist (EC50=30 μM) and is selective. Fenofibrate also inhibits cytochrome P450 isoforms, such as CYP2C19, CYP2B6, CYP2C9, CYP2C8, and CYP3A4. Fenofibrate exhibits antihyperlipidemic activity.
- $32
Size
QTY
CitedPHYTOL
trans-Phytol, (E)-Phytol
T3254150-86-7
PHYTOL (trans-Phytol) , a diterpene alcohol from chlorophyll widely used as a food additive and in medicinal fields, shows antinociceptive and antioxidant activities as well as anti-inflammatory and antiallergic effects. It is a specific activator of PPARα.
- $42
Size
QTY
Icariin Cited
Ieariline
T2855489-32-7
Icariin (Ieariline) belongs to the flavonol glycoside group of natural products, can inhibit PDE5 and PDE4 activity (IC50=432/73.50 μM), is also a PPARα activator. Icariin can increase cardiovascular and cerebrovascular blood flow, promote hematopoiesis, immunity and bone metabolism.
- $33
Size
QTY
CitedPioglitazone hydrochloride Cited
U-72107E, U 72107A, Pioglitazone HCl, AD 4833
T0214L112529-15-4
Pioglitazone hydrochloride (AD 4833) is the hydrochloride salt of an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
- $35
Size
QTY
Cited(S)-(+)-Ibuprofen
Dexibuprofen, (S)-Ibuprofen
T044851146-56-6
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
- $35
Size
QTY
Cinnamyl alcohol
Styryl Carbinol, Cinnamic Alcohol
T5S1550104-54-1
Cinnamyl alcohol (Styryl Carbinol) readily autoxidizes upon air exposure, and forms strong sensitizers as determined by the local lymph node assay.
- $31
Size
QTY
Select Batch
Purity:98.87%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | LY518674 (LY-674) decreases triglycerides and increases HDL-C and is used for the treatment of atherosclerosis. LY518674 is an effective and selective PPARα agonist (EC50: 42 nM for human PPARα). |
| Targets&IC50 | PPARα:42 nM (EC50 human) |
| In vivo | LY518674 decreases triglycerides and increased HDL-C in vivo[2]. LY518674 significantly enhances apolipoprotein A-I (apoA-I) turnover without a major impact on steady-state levels of apoA-I or high-density lipoprotein-cholesterol (HDL-C) [3]. |
| Alias | LY-674 |
| Molecular Weight | 409.48 |
| Formula | C23H27N3O4 |
| Cas No. | 425671-29-0 |
| Smiles | Cc1ccc(Cn2[nH]c(CCCc3ccc(OC(C)(C)C(O)=O)cc3)nc2=O)cc1 |
| Relative Density. | 1.21g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (610.53 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy LY518674 | purchase LY518674 | LY518674 cost | order LY518674 | LY518674 chemical structure | LY518674 in vivo | LY518674 formula | LY518674 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.