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Linaprazan

Linaprazan
Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase through K+-competitive binding, with an IC50 of 1.0 μM.
Catalog No. T10435Cas No. 248919-64-4
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Purity:99.63%
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Linaprazan

Catalog No. T10435Cas No. 248919-64-4
Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase through K+-competitive binding, with an IC50 of 1.0 μM.
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Pack SizePriceAvailabilityQuantity
5 mg$43In Stock
10 mg$73In Stock
25 mg$148In Stock
50 mg$223In Stock
100 mg$375In Stock
1 mL x 10 mM (in DMSO)$47In Stock
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Product Introduction

Bioactivity
Description
Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase through K+-competitive binding, with an IC50 of 1.0 μM.
Targets&IC50
K+ competitive binding:1.0 μM
In vitro
Linaprazan (AZD0865) can inhibit the final step in acid secretion. Linaprazanreduced porcine renal Na+, K+-ATPase activity by 9 ± 2% [1].
In vivo
The reference for animal administration is 0.5-1.0 mg/kg. The greater degree of acid suppression with the 75-mg dose of Linaprazan would translate to a healing rate of 89% at 4 weeks [2].
AliasAZD0865
Chemical Properties
Molecular Weight366.46
FormulaC21H26N4O2
Cas No.248919-64-4
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 3.67 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7288 mL13.6441 mL27.2881 mL136.4405 mL
5 mM0.5458 mL2.7288 mL5.4576 mL27.2881 mL
10 mM0.2729 mL1.3644 mL2.7288 mL13.6441 mL

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