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Lofexidine

Lofexidine
Lofexidine, a selective α2-receptor agonist, reduces narcotic withdrawal symptoms.
Catalog No. T7160Cas No. 31036-80-3
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Purity:98.78%
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Lofexidine

Catalog No. T7160Cas No. 31036-80-3
Lofexidine, a selective α2-receptor agonist, reduces narcotic withdrawal symptoms.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$30In Stock
50 mg$85In Stock
1 mL x 10 mM (in DMSO)$30In Stock
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Product Introduction

Bioactivity
Description
Lofexidine, a selective α2-receptor agonist, reduces narcotic withdrawal symptoms.
In vivo
Lofexidine significantly decreased SOWS scores compared to placebo and demonstrated better retention rates in participants undergoing opioid withdrawal. Lofexidine potentially offers a useful non-opioid alternative to treat opioid withdrawal symptoms[1].
Animal Research
8-day, randomized, double-blind, placebo-controlled, parallel-group study in 264 patients dependent on short-acting opioids evaluated the efficacy of lofexidine hydrochloride in reducing withdrawal symptoms in patients undergoing opioid withdrawal.?The primary efficacy measures were SOWS-Gossop on Day 3 and time-to-dropout.?Secondary endpoints included the proportion of participants who were completers;?area under the 5-day SOWS-Gossop - time curve (i.e., AUC1-5), and daily mean SOWS-Gossop, OOWS-Handelsman, MCGI (subject and rater), and VAS-E scores.?Participants received lofexidine HCl 3.2mg daily in four divided doses or matching placebo on Days 1-5, followed by 2days of placebo[1].
Chemical Properties
Molecular Weight259.13
FormulaC11H12Cl2N2O
Cas No.31036-80-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 62.5 mg/mL (241.19 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.8591 mL19.2953 mL38.5907 mL192.9533 mL
5 mM0.7718 mL3.8591 mL7.7181 mL38.5907 mL
10 mM0.3859 mL1.9295 mL3.8591 mL19.2953 mL
20 mM0.1930 mL0.9648 mL1.9295 mL9.6477 mL
50 mM0.0772 mL0.3859 mL0.7718 mL3.8591 mL
100 mM0.0386 mL0.1930 mL0.3859 mL1.9295 mL

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