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MBM-55S

Catalog No. T11961 CAS 2083624-07-9

MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer cells. MBM-55S shows antitumor activities.

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MBM-55S, CAS 2083624-07-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 195.00
2 mg	In stock	$ 293.00
5 mg	In stock	$ 449.00
10 mg	In stock	$ 659.00
25 mg	In stock	$ 987.00
50 mg	In stock	$ 1,390.00
100 mg	In stock	$ 1,880.00
500 mg	In stock	$ 3,780.00
1 mL * 10 mM (in DMSO)	In stock	$ 663.00

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Purity: 98.73%

Purity: 98.38%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer cells. MBM-55S shows antitumor activities.
Targets&IC50	Aurora A:5300 nM , Chk1:57 nM , DYRK1A:6.5 nM , CDK4:441nM , Abl:20 nM , CDK2:370 nM , NEK2:1 nM , GSK-3β:91 nM , Akt1:608 nM , RSK1:5.4 nM
In vitro	MBM-55S shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 and DYRK1a with IC50s of 5.4 and 6.5 nM. MBM-55S inhibits MGC-803, HCT-116, and Bel-7402 the proliferation of cell with IC50s of 0.53, 0.84, and 7.13 μM, respectively. MBM-55S (0.5-1 μM) induces G2/M phase arrest and accumulation of cells with >4N content and causes cell apoptosis in a concentration-dependent manner in HCT-116 cells[1].
In vivo	In female BALB/c nu/nu mice, MBM-55S (20 mg/kg; i.p) exhibits good antitumor activity. In male Sprague Dawley rats, MBM-55S (1.0 mg/kg; i.v.) shows good pharmacokinetic profile with the CL, T1/2, Vss, AUC0-t, and AUC0-∞ values of 33.3 mL/min/kg, 1.72 hours, 2.53 L/kg, 495 ng/h/mL and 507 ng/h/mL, respectively[1].

Molecular Weight	734.73
Formula	C36H39FN6O10
CAS No.	2083624-07-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5 mg/mL (30.62 mM)

References and Literature

1. Xi JB, et al. Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem. 2017 Jan 27;126:1083-1106.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library Antidepressant Compound Library Anti-Breast Cancer Compound Library Kinase Inhibitor Library Anti-Lung Cancer Compound Library Anti-Obesity Compound Library Anti-Pancreatic Cancer Compound Library Anti-Cancer Metabolism Compound Library

Related Products

Related compounds with same targets

GSK3-IN-2 CHIR-99021 GSK-3 inhibitor 1 GSK3-IN-4 GSK-3 Inhibitor 5 ARN25068 A 1070722 CHIR-124

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Keywords

MBM-55S 2083624-07-9 Angiogenesis Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling MAPK PI3K/Akt/mTOR signaling Stem Cells Tyrosine Kinase/Adaptors GSK-3 S6 Kinase CDK Aurora Kinase Akt Bcr-Abl MBM 55S MBM55S inhibitor inhibit

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