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MKC8866
🥰Excellent
Catalog No. T15594Cas No. 1338934-59-0
MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate cancer (PCa) tumor growth.
MKC8866
🥰Excellent
Purity: 99.35%
Catalog No. T15594Cas No. 1338934-59-0
MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate cancer (PCa) tumor growth.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $80 | In Stock | |
| 5 mg | $197 | In Stock | |
| 10 mg | $320 | In Stock | |
| 25 mg | $538 | In Stock | |
| 50 mg | $779 | In Stock | |
| 100 mg | $1,090 | In Stock | |
| 500 mg | $2,180 | In Stock |
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Purity:99.35%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | MKC8866 is a selective IRE1 RNase inhibitor (IC50: 0.29 μM in human vitro). MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibit prostate cancer (PCa) tumor growth. |
| Targets&IC50 | IRE1 Rnase:0.29 μM |
| In vitro | MKC8866 strongly suppresses DTT-induced X-box-binding protein 1-spliced (XBP1s) expression (EC50: 0.52?μM) and unstressed RPMI 8226 cells (IC50: 0.14?μM). MKC8866 (0.2-10 μM; 3 days) inhibits the viability of all four cell lines in a dose-dependent manner under normal conditions, with the most robust effect in LNCaP cells, and MKC8866 (20 μM; 72?hours) is sufficient to completely block NSC 125973-induced expression of XBP1s [1]. MKC8866 (20?μM; 6 days) reduces the proliferation of all breast cancer cell lines and MKC8866 (20 μM; 48 hours) decreases the number of cells entering the S phase [2]. |
| In vivo | MKC8866 (oral; 300 mg/kg; for 28 days) reduces tumor regrowth following NSC 125973 withdrawal [1]. |
| Molecular Weight | 361.35 |
| Formula | C18H19NO7 |
| Cas No. | 1338934-59-0 |
| Smiles | COc1cc2c(C)c(CC(=O)N3CCOCC3)c(=O)oc2c(C=O)c1O |
| Relative Density. | 1.373 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 3.61 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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