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ML-9

Catalog No. T16104 CAS 105637-50-1

ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) activity. ML-9 causes autophagy by stimulating autophagosome formation and inhibiting their degradation.

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ML-9, CAS 105637-50-1

Pack Size	Availability	Price/USD
5 mg	In stock	$ 34.00
10 mg	In stock	$ 52.00
25 mg	In stock	$ 97.00
50 mg	In stock	$ 158.00
100 mg	In stock	$ 235.00
1 mL * 10 mM (in DMSO)	In stock	$ 37.00

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Purity: 99.6%

Biological Description

Chemical Properties

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Description	ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) activity. ML-9 causes autophagy by stimulating autophagosome formation and inhibiting their degradation.
In vitro	ML9 (50?μM; 1-4?hours) obviously enhances cleaved caspase-3 levels, reduced STIM1 protein levels by about 42%. ML9 (0-100?μM; 0-24?hours) has no reduction in cardiomyocyte viability, 50-100?μM obviously causes cell death [2].

Molecular Weight	361.29
Formula	C15H18Cl2N2O2S
CAS No.	105637-50-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (69.2 mM)

References and Literature

1. Ito S, et al. ML-9, a myosin light chain kinase inhibitor, reduces intracellular Ca2+ concentration in guinea pig trachealis.Eur J Pharmacol. 2004 Feb 23;486(3):325-33. 2. Shaikh S, et al. The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content.Toxicol In Vitro. 2018 Apr;48:121-127. 3. Kondratskyi A1, et al.Identification of ML-9 as a lysosomotropic agent targeting autophagy and cell death.Cell Death Dis. 2014 Apr 24;5:e1193.

Citations

1. Sun L, Sun L, Li X, et al. A Novel Tigecycline Adjuvant ML-7 Reverses the Susceptibility of Tigecycline-Resistant Klebsiella pneumoniae. Frontiers in cellular and infection microbiology. 2022: 1341.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Inhibitor Library PI3K-AKT-mTOR Compound Library Glycolysis Compound Library Anti-Colorectal Cancer Compound Library Oxidation-Reduction Compound Library Anti-Breast Cancer Compound Library Anti-Cancer Metabolism Compound Library Anti-Pancreatic Cancer Compound Library Antidepressant Compound Library

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BTS JB061 Danicamtiv Blebbistatin Phenamacril ML-7 hydrochloride para-Nitroblebbistatin HA-100

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Keywords

ML-9 105637-50-1 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Myosin Akt viability STIM1 Inhibitor ML9 MLCK caspase inhibit ML 9 cardiomyocyte inhibitor

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