Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3(IC50s of 1.3 nM and 0.64 nM, respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 59.00 | |
5 mg | In stock | $ 147.00 | |
10 mg | In stock | $ 239.00 | |
25 mg | In stock | $ 478.00 | |
50 mg | In stock | $ 689.00 | |
100 mg | In stock | $ 982.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 159.00 |
Description | MRX-2843 (UNC2371) is a potent and orally active inhibitor of MERTK and FLT3(IC50s of 1.3 nM and 0.64 nM, respectively). |
Targets&IC50 | FLT3:0.64 nM, MerTK:1.3 nM |
In vitro | MRX-2843, a type 1 small-molecule tyrosine kinase inhibitor that abrogates activation of both MERTK and FLT3 and their downstream effectors.?MRX-2843 treatment induces apoptosis and inhibits colony formation in AML cell lines and primary patient samples expressing MERTK and/or FLT3-ITD, with a wide therapeutic window compared with that of normal human cord blood cells[1]. |
In vivo | In murine orthotopic xenograft models, once-daily oral therapy prolonged survival 2- to 3-fold over that of vehicle-treated controls.?Additionally, MRX-2843 retained activity against quizartinib-resistant FLT3-ITD-mutant proteins with clinically relevant alterations at the D835 or F691 loci and prolonged survival in xenograft models of quizartinib-resistant AML.?Together, these observations validate MRX-2843 as a translational agent and support its clinical development for the treatment of AML[1]. |
Synonyms | UNC2371 |
Molecular Weight | 488.67 |
Formula | C29H40N6O |
CAS No. | 1429882-07-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 26.25 mg/mL (53.72 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MRX-2843 1429882-07-4 Angiogenesis Others Tyrosine Kinase/Adaptors FLT UNC-2371 FLT3 MRX2843 Fms like tyrosine kinase 3 CD135 MRX 2843 inhibit Cluster of differentiation antigen 135 Inhibitor UNC2371 UNC 2371 inhibitor