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MYCi361

Catalog No. T12132   CAS 2289690-31-7
Synonyms: NUCC-0196361

MYCi361 (NUCC-0196361) is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).

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MYCi361 Chemical Structure
MYCi361, CAS 2289690-31-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 118.00
5 mg In stock $ 287.00
10 mg In stock $ 457.00
25 mg In stock $ 753.00
50 mg In stock $ 1,060.00
100 mg In stock $ 1,430.00
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Purity: 99.13%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description MYCi361 (NUCC-0196361) is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).
Targets&IC50 MYC:3.2 μM(Kd)
In vitro MYCi361 is a small-molecule MYC inhibitors that inhibits the viability of MYC-dependent cancer cells including prostate cancer (MycCaP, LNCaP, and PC3), leukemia (MV4-11), lymphoma (HL-60 and P493-6), and neuroblastoma (SK-N-B2) with low-micromolar IC50 values[1].
In vivo MYC inhibitor 361 (MYCi361), suppressed in vivo tumor growth in mice, increased tumor immune cell infiltration, upregulated PD-L1 on tumors, and sensitized tumors to anti-PD1 immunotherapy.
Animal Research FVB or NSG male mice of 6-8 weeks of age and 25 g bearing established MycCaP tumors.MYCi361 treatment i.p. initially at 50 mg/kg twice daily for 2 days, then 70 mg/kg/day for 9 days
Synonyms NUCC-0196361
Molecular Weight 594.86
Formula C26H16ClF9N2O2
CAS No. 2289690-31-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (168.1 mM), sonification is recommended.

TargetMolReferences and Literature

1. Han H, et al. Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy. Cancer Cell. 2019 Nov 11;36(5):483-497.e15.

TargetMolCitations

1. Ram B M, Dai C.Detection of the DNA binding of transcription factors in situ at the single-cell resolution in cultured cells by proximity ligation assay.STAR protocols.2023, 4(4): 102692.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Glutamine Metabolism Compound Library Bioactive Compound Library Immunology/Inflammation Compound Library Glycolysis Compound Library Wnt/Hedgehog/Notch Compound Library NO PAINS Compound Library Apoptosis Compound Library Anti-Cancer Metabolism Compound Library Bioactive Compounds Library Max

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MDEG-541 Moracin D Moracin T MYC-RIBOTAC 10058-F4 Lusianthridin APTO-253 MYCi975

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Keywords

MYCi361 2289690-31-7 Cell Cycle/Checkpoint c-Myc MYCi 361 NUCC0196361 NUCC 0196361 MYCi-361 NUCC-0196361 inhibit Inhibitor Myc inhibitor

 

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