Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Merafloxacin (CI 934) is a fluoroquinolone antibacterial, which was also identified as a 1 PRF inhibitor of SARS-CoV-2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 56.00 | |
2 mg | In stock | $ 79.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 198.00 | |
25 mg | In stock | $ 363.00 | |
50 mg | In stock | $ 539.00 | |
100 mg | In stock | $ 778.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 133.00 |
Description | Merafloxacin (CI 934) is a fluoroquinolone antibacterial, which was also identified as a 1 PRF inhibitor of SARS-CoV-2. |
Targets&IC50 | SARS-CoV-2:19.6 μM (IC50) |
In vitro | Frameshift inhibition by merafloxacin is robust to mutations within the pseudoknot region and is similarly effective on -1 PRF of other beta coronaviruses.?Importantly, frameshift inhibition by merafloxacin substantially impedes SARS-CoV-2 replication in Vero E6 cells, thereby providing the proof of principle of targeting -1 PRF as an effective antiviral strategy for SARS-CoV-2. |
Synonyms | CI 934 |
Molecular Weight | 379.4 |
Formula | C19H23F2N3O3 |
CAS No. | 91188-00-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Merafloxacin 91188-00-0 Microbiology/Virology SARS-CoV CI 934 frameshifting bacteria antibacterial fluoroquinolone Inhibitor CI-934 gram-positive inhibit programmed coronaviruses CI934 ribosomal PRF gram-negative SARS coronavirus inhibitor