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Midaglizole hydrochloride

Catalog No. T11015 CAS 79689-25-1

Synonyms: (±)-DG5128, (±)-DG5128 hydrochloride, DG5128 hydrochloride, DG5128

Midaglizole hydrochloride ((±)-DG5128) (DG5128) is a preferred α2-adrenoceptor antagonist. Midazolazole hydrochloride (DG5128) has an affinity for α2-adrenoceptor (pKi = 6.28) 7.4 times higher than that of α1-adrenoceptor.

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Midaglizole hydrochloride Chemical Structure

Midaglizole hydrochloride, CAS 79689-25-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 145.00
5 mg	In stock	$ 356.00
10 mg	In stock	$ 583.00
25 mg	In stock	$ 949.00
50 mg	In stock	$ 1,290.00
100 mg	In stock	$ 1,730.00
500 mg	In stock	$ 3,470.00
1 mL * 10 mM (in DMSO)	In stock	$ 453.00

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Purity: 100%

Purity: 98.73%

Biological Description

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Description	Midaglizole hydrochloride ((±)-DG5128) (DG5128) is a preferred α2-adrenoceptor antagonist. Midazolazole hydrochloride (DG5128) has an affinity for α2-adrenoceptor (pKi = 6.28) 7.4 times higher than that of α1-adrenoceptor.
Targets&IC50	α2-adrenoceptor:6.28(pKi )
In vitro	The inhibitory effect of midazolam (DG-5128) at a concentration of up to 10 μM in the cerebral cerebral membrane of [3H] clonidine is more effective than that of [3H] prazosin. The suppression method is uniform and conforms to the simple law of mass action. The EC50 values of midazolazole-induced insulin release in rat pancreatic islets and MIN6β cell lines were 200 nM and 24 μM, respectively. The IC50 values of midazolam for Kir6.2 and Kir6.2/SUR1 induced KATP current were 3.8 μM and 4.4 uM, respectively.
In vivo	Midaglizole (3 and 30 mg/kg, i.v.) increases blood pressure in pithed rats[1].

Synonyms	(±)-DG5128, (±)-DG5128 hydrochloride, DG5128 hydrochloride, DG5128
Molecular Weight	324.25
Formula	C16H19Cl2N3
CAS No.	79689-25-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 450 mg/mL (1387.8 mM), Sonication and heating to 60℃ are recommended.

References and Literature

1. Yamanaka K, et al. The selectivity of DG-5128 as an alpha 2-adrenoceptor antagonist. Eur J Pharmacol. 1984 Nov 27;106(3):625-8. 2. Proks P, et al. Inhibition of recombinant K(ATP) channels by the antidiabetic agents midaglizole, LY397364 and LY389382. Eur J Pharmacol. 2002 Sep 27;452(1):11-9. 3. Hirohashi M, et al. Intrinsic pressor activity of midaglizole, an alpha-2 adrenoceptor antagonist, in pithed rats. Jpn J Pharmacol. 1990 Aug;53(4):519-20.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Membrane Protein-targeted Compound Library Inhibitor Library Neuronal Signaling Compound Library Anti-Cancer Compound Library Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

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