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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $87 | In Stock | |
5 mg | $213 | In Stock | |
10 mg | $349 | In Stock | |
25 mg | $569 | In Stock | |
50 mg | $774 | In Stock | |
100 mg | $987 | In Stock | |
500 mg | $1,980 | In Stock | |
1 mL x 10 mM (in DMSO) | $271 | In Stock |
Description | Midaglizole hydrochloride ((±)-DG5128) (DG5128) is a preferred α2-adrenoceptor antagonist. Midazolazole hydrochloride (DG5128) has an affinity for α2-adrenoceptor (pKi = 6.28) 7.4 times higher than that of α1-adrenoceptor. |
Targets&IC50 | α2-adrenoceptor:6.28(pKi ) |
In vitro | The inhibitory effect of midazolam (DG-5128) at a concentration of up to 10 μM in the cerebral cerebral membrane of [3H] clonidine is more effective than that of [3H] prazosin. The suppression method is uniform and conforms to the simple law of mass action. The EC50 values of midazolazole-induced insulin release in rat pancreatic islets and MIN6β cell lines were 200 nM and 24 μM, respectively. The IC50 values of midazolam for Kir6.2 and Kir6.2/SUR1 induced KATP current were 3.8 μM and 4.4 uM, respectively. |
In vivo | Midaglizole (3 and 30 mg/kg, i.v.) elevates blood pressure in pithed rats[1]. |
Alias | (±)-DG5128, (±)-DG5128 hydrochloride, DG5128 hydrochloride, DG5128 |
Molecular Weight | 324.25 |
Formula | C16H19Cl2N3 |
Cas No. | 79689-25-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (138.78 mM), Sonication and heating to 60℃ are recommended. ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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