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NM-3

NM-3
NM-3 is an orally available anti-angiogenic inhibitor with anti-tumour activity.NM-3 is used as a radiation modulator in vitro and in vivo.NM-3 inhibits vascular endothelial growth factor (VEGF), thereby inhibiting the proliferation of endothelial cells. This inhibits the proliferation of endothelial cells. NM-3 is associated with a mechanism of apoptosis induction by reactive oxygen species.
Catalog No. T33701Cas No. 181427-78-1
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Purity:99%
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NM-3

Purity: 99%
Catalog No. T33701Alias NM-3, NM3, NM 3, Isocoumarin NM-3, isocoumarinCas No. 181427-78-1

NM-3 is an orally available anti-angiogenic inhibitor with anti-tumour activity.NM-3 is used as a radiation modulator in vitro and in vivo.NM-3 inhibits vascular endothelial growth factor (VEGF), thereby inhibiting the proliferation of endothelial cells. This inhibits the proliferation of endothelial cells. NM-3 is associated with a mechanism of apoptosis induction by reactive oxygen species.
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Pack SizePriceAvailabilityQuantity
1 mg$190In Stock
5 mg$480In Stock
10 mg$687In Stock
25 mg$1,080In Stock
50 mg$1,480In Stock
100 mg$1,990In Stock
500 mg$3,920In Stock
1 mL x 10 mM (in DMSO)$438In Stock
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Product Introduction

Bioactivity
Description
NM-3 is an orally available anti-angiogenic inhibitor with anti-tumour activity.NM-3 is used as a radiation modulator in vitro and in vivo.NM-3 inhibits vascular endothelial growth factor (VEGF), thereby inhibiting the proliferation of endothelial cells. This inhibits the proliferation of endothelial cells. NM-3 is associated with a mechanism of apoptosis induction by reactive oxygen species.
In vitro
NM-3 (100 ng/ml) is cytotoxic to human umbilical vein endothelial cells (HUVECs) but not to Lewis lung carcinoma (LLC) cells nor Seg-1, esophageal adenocarcinoma cells, in clonogenic survival assays (1,000 ng/ml ; 4h).[1]
In vivo
C57BL/6 female mice bearing LLC tumors were given injections for 4 consecutive days with NM-3 (25 mg/kg/day) and treated with IR (20 Gy) for 2 consecutive days. Combined treatment with NM-3 and IR significantly reduced mean tumor volume compared with either treatment alone. An increase in local tumor control was also observed in LLC tumors in mice receiving NM-3/IR therapy. When athymic nude mice bearing Seg-1 tumor xenografts were treated with NM-3 (100 mg/kg/day for 4 days) and 20 Gy (four 5 Gy fractions), significant tumor regression was observed after combined treatment (NM-3 and IR) compared with IR alone. Importantly, no increase in systemic or local tissue toxicity was observed after combined treatment (NM-3 and IR) when compared with IR alone. The bioavailability and nontoxic profile of NM-3 suggests that the efficacy of this agent should be tested in clinical radiotherapy.[1]
AliasNM-3, NM3, NM 3, Isocoumarin NM-3, isocoumarin
Chemical Properties
Molecular Weight264.23
FormulaC13H12O6
Cas No.181427-78-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 27.5 mg/mL (104.08 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7846 mL18.9229 mL37.8458 mL189.2291 mL
5 mM0.7569 mL3.7846 mL7.5692 mL37.8458 mL
10 mM0.3785 mL1.8923 mL3.7846 mL18.9229 mL
20 mM0.1892 mL0.9461 mL1.8923 mL9.4615 mL
50 mM0.0757 mL0.3785 mL0.7569 mL3.7846 mL
100 mM0.0378 mL0.1892 mL0.3785 mL1.8923 mL

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