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NS1652
NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.
Catalog No. T16346Cas No. 1566-81-0
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Purity:99.62%
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NS1652
Catalog No. T16346Cas No. 1566-81-0
NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 5 mg | $107 | In Stock | |
| 10 mg | $173 | In Stock | |
| 25 mg | $323 | In Stock | |
| 50 mg | $467 | In Stock | |
| 100 mg | $636 | In Stock | |
| 200 mg | $857 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | NS1652 is an anion conductance inhibitor. NS1652 blocks chloride channel has an IC50 of 1.6 μM in human and mouse red blood cells. |
| Targets&IC50 | Cl- channel (human and mouse red blood cells):1.6 μM (IC50) |
| In vitro | NS1652 (20 μM) fully and reversibly inhibits the red cell Cl-conductance. NS1652 effectively inhibits the chloride conductance (IC50, 1.6 μM) in human and mouse red blood cells, but only weakly inhibits VRAC (IC50, 125 μM) in HEK293 cells. NS1652 markedly blocks the NO production (IC50: 3.1 μM in BV2 cells). NS1652 also down-regulates iNOS expression at 3 μM and fully abolishes at 10 μM in BV2 cells. NS1652 (0, 1.0, 3.3, 10, and 20 μM) induces increasing hyperpolarization due to inhibition of the chloride conductance in normal erythrocytes. NS1652 lowers the net KCl loss from deoxygenated sickle cells from about 12 mM cells/h to about 4 mM cells/h [1][2]. |
| In vivo | In mice, NS1652 (50 mg/kg, i.v.) blocks murine erythrocyte Cl- conductance by >90%[2]. |
| Molecular Weight | 324.25 |
| Formula | C15H11F3N2O3 |
| Cas No. | 1566-81-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.9 mg/mL (15.11 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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