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NS5806

NS5806
NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2. NS5806 enhances KV4.3/KChIP2 peak current amplitudes (EC50: 5.3 μM).
Catalog No. T16348Cas No. 426834-69-7
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Purity:97.95%
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NS5806

Purity: 97.95%
Catalog No. T16348Alias NS-5806Cas No. 426834-69-7

NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2. NS5806 enhances KV4.3/KChIP2 peak current amplitudes (EC50: 5.3 μM).
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Pack SizePriceAvailabilityQuantity
2 mg$34In Stock
5 mg$58In Stock
10 mg$93In Stock
25 mg$157In Stock
50 mg$233In Stock
100 mg$343In Stock
1 mL x 10 mM (in DMSO)$74In Stock
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Product Introduction

Bioactivity
Description
NS5806 is an effective potassium current activator. NS5806 slows KV4.3 and KV4.2 current decay in channel complexes containing KChIP2. NS5806 enhances KV4.3/KChIP2 peak current amplitudes (EC50: 5.3 μM).
Targets&IC50
Kv4.3/KChIP2:5.3 μM
In vitro
NS5806 activates canine transient outward potassium current (Ito) (IC50: 40.7 nM and an EC50 of 1.6 nM for inhibition and stimulation on the rabbit, respectively). NS5806 (10-100 nM) has concentration-dependent effects on ventricular and atrial Ito. NS5806 (10 μM) induces a 65% increase of KV4.3/KChIP2/DPP6 peak current amplitudes concentration-dependently and the time course of inactivation (τ) is slowed with an EC50 value of 25.4 μM in CHO-K1 cells[1][2].
AliasNS-5806
Chemical Properties
Molecular Weight574.07
FormulaC16H8Br2F6N6O
Cas No.426834-69-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 250 mg/mL (435.49 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7419 mL8.7097 mL17.4195 mL87.0974 mL
5 mM0.3484 mL1.7419 mL3.4839 mL17.4195 mL
10 mM0.1742 mL0.8710 mL1.7419 mL8.7097 mL
20 mM0.0871 mL0.4355 mL0.8710 mL4.3549 mL
50 mM0.0348 mL0.1742 mL0.3484 mL1.7419 mL
100 mM0.0174 mL0.0871 mL0.1742 mL0.8710 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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