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Nepodin

Catalog No. TN1100 CAS 3785-24-8

Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, which is at least partly mediated by stimulation of GLUT4 translocation via AMPK activation by nepodin.

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Nepodin, CAS 3785-24-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 98.00
5 mg	In stock	$ 247.00
10 mg	In stock	$ 397.00
25 mg	In stock	$ 652.00
50 mg	In stock	$ 913.00
100 mg	In stock	$ 1,230.00
1 mL * 10 mM (in DMSO)	In stock	$ 222.00

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Purity: 99.12%

Purity: 98.54%

Purity: 98.5%

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Description	Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, which is at least partly mediated by stimulation of GLUT4 translocation via AMPK activation by nepodin.
In vitro	To obtain a novel modulator of glucose metabolism, we conducted screening of a small compound library in cultured L6 myotubes. We identified Nepodin that stimulated glucose uptake dose-dependently in differentiated L6 myotubes. The stimulatory effect of Nepodin on glucose uptake was abrogated by a 5'-adenosine monophosphate-activated protein kinase (AMPK) inhibitor. In addition, Nepodin stimulated the phosphorylation of AMPK. Nepodin also stimulated the translocation of GLUT4 to the plasma membrane in L6 myoblasts transfected with a Glut4 cDNA-coding vector and in differentiated L6 myotubes. In in vivo study, Nepodin suppressed the increases in fasting blood glucose levels and improved the glucose intolerance of C57BL/KsJ-db/db mice, a type 2 diabetic animal model. Nepodin rescued the impaired phosphorylation of AMPK in the skeletal muscle of db/db mice[1]
Source	Natural Products > Polygonaceae > Rumex

Molecular Weight	216.23
Formula	C13H12O3
CAS No.	3785-24-8

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (231.24 mM)

References and Literature

1. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo.Biofactors. 2014 Jul-Aug;40(4):436-47.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Antiparasitic Natural Product Library Anti-Parasitic Compound Library Inhibitor Library Neuronal Signaling Compound Library Anti-Prostate Cancer Compound Library PI3K-AKT-mTOR Compound Library Anti-Ovarian Cancer Compound Library NO PAINS Compound Library Anti-Breast Cancer Compound Library

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Keywords

Nepodin 3785-24-8 Chromatin/Epigenetic Immunology/Inflammation Metabolism Microbiology/Virology Neuroscience PI3K/Akt/mTOR signaling transporter COX AMPK Parasite Inhibitor AMP-activated protein kinase Musizin inhibit inhibitor

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