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ON 146040

Catalog No. T12310 CAS 1404231-34-0

Synonyms: ZINC211117138

ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.

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ON 146040, CAS 1404231-34-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 97.00
2 mg	In stock	$ 147.00
5 mg	In stock	$ 247.00
10 mg	In stock	$ 397.00
25 mg	In stock	$ 652.00
50 mg	In stock	$ 913.00
100 mg	In stock	$ 1,230.00
500 mg	In stock	$ 2,460.00
1 mL * 10 mM (in DMSO)	In stock	$ 287.00

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Purity: 99.89%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ON 146040 is an effective inhibitor of PI3K isoforms with IC50s of 14 and 20 nM for PI3Kα and PI3Kδ, respectively.
Targets&IC50	PI3Kγ:1 μM, Abl-1:150 nM, PI3Kα:14 nM, PI3Kβ:3 μM, PI3Kδ:20 nM
In vitro	ON 146040 inhibits Abl1 and several mutant versions of this kinase with IC50 < 150 nM. ON 146040 is highly potent in killing hematologic tumor cells with IC50 values in the 150 to 1000 nM range. ON 146040 downregulates the phosphorylation of STAT3 and STAT5 in leukemia and myeloma cells[1].

Synonyms	ZINC211117138
Molecular Weight	489.55
Formula	C24H23N7O3S
CAS No.	1404231-34-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 4.9 mg/mL (10 mM)

References and Literature

1. Stephen Cosenza, et al. Targeting oncogenic STAT3 and STAT5 signaling with on 146040, a small molecule inhibitor of PI3K α/δ and BCR-ABL. Journal of Clinical Oncology 2014 32:15

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Tyrosine Kinase Inhibitor Library Anti-Colorectal Cancer Compound Library Anti-Lung Cancer Compound Library Anti-Ovarian Cancer Compound Library Antidepressant Compound Library Anti-Obesity Compound Library Kinase Inhibitor Library Bioactive Compounds Library Max Metabolism Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ON 146040 1404231-34-0 Angiogenesis Cytoskeletal Signaling PI3K/Akt/mTOR signaling Tyrosine Kinase/Adaptors PI3K Bcr-Abl ON146040 ON-146040 ZINC-211117138 ZINC 211117138 ZINC211117138 inhibitor inhibit

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