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OSS_128167

Catalog No. T4328   CAS 887686-02-4
Synonyms: SIRT6-IN-1

OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).

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OSS_128167 Chemical Structure
OSS_128167, CAS 887686-02-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 38.00
2 mg In stock $ 54.00
5 mg In stock $ 85.00
10 mg In stock $ 119.00
25 mg In stock $ 247.00
50 mg In stock $ 455.00
100 mg In stock $ 672.00
500 mg In stock $ 1,430.00
1 mL * 10 mM (in DMSO) In stock $ 85.00
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Purity: 99.25%
Purity: 99.25%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor, and for SIRT6(IC50=89 μM), SIRT1(IC50=1578 μM) and SIRT2(IC50=751 μM).
Targets&IC50 SIRT2 (Cell-free):751 μM, SIRT6 (Cell-free):89 μM, SIRT1(Cell-free):1578 μM
In vitro OSS-128167 increases H3K9 acetylation and GLUT-1 expression, and proves to be a selective compounds toward SIRT6.
Kinase Assay In supernatants from cells, which are incubated in OSS_128167 (100 μM) for 18 hours,TNF-a levels are measured .
Cell Research BxPC3 cells are stimulated with 100 μM OSS-128167 incubating 0, 2, 6, 18, 24 hours.
Synonyms SIRT6-IN-1
Molecular Weight 366.32
Formula C19H14N2O6
CAS No. 887686-02-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 68 mg/mL (185.6 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Parenti MD, et al. Discovery of novel and selective SIRT6 inhibitors. J Med Chem. 2014 Jun 12;57(11):4796-804. 2. Cea M, et al. Evidence for a role of the histone deacetylase SIRT6 in DNA damage response of multiple myeloma cells. Blood. 2016 Mar 3;127(9):1138-50.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Viral Compound Library Anti-Aging Compound Library HIF-1 Signaling Pathway Compound Library Anti-Infection Compound Library NO PAINS Compound Library Inhibitor Library Bioactive Compound Library Reprogramming Compound Library Chromatin Modification Compound Library

Related Products

Related compounds with same targets
Dihydrocoumarin SIRT1-IN-1 Et-29 Sirtinol SIRT6-IN-3 5-Feruloylquinic acid Selisistat R-enantiomer MC3482

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Keywords

OSS_128167 887686-02-4 Chromatin/Epigenetic DNA Damage/DNA Repair Microbiology/Virology HBV Sirtuin SIRT6 deacetylase TNF-α SIRT6-IN-1 immune antiviral inhibit PPARα H3K9 acetylation anti-cancer Hepatitis B virus Inhibitor diabetes GLUT-1 chemosensitization inhibitor

 

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