Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Orotic acid (Vitamin B13) is an intermediate product in pyrimidine metabolism.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 38.00 | |
100 mg | In stock | $ 50.00 | |
200 mg | In stock | $ 58.00 | |
500 mg | In stock | $ 93.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Orotic acid (Vitamin B13) is an intermediate product in pyrimidine metabolism. |
In vitro | Orotic acid increases cell proliferation and decreases apoptosis in serum-starved SK-Hep1 hepatocellular carcinoma cells, which may ascribe to the inhibition of AMP-activated protein kinase (AMPK) phosphorylation and thus activation of mammalian target of rapamycin complex 1 (mTORC1) [1]. |
In vivo | Male Fischer 344 rats (130-150 g) to two-thirds PH in the absence or in the presence of Orotic acid (a 300-mg tablet of Orotic acid methyl ester implanted intraperitoneally at the time of two-thirds PH). treatment with Orotic acid resulted in a near-100% inhibition of RNR induced by two-thirds PH in rat liver, as monitored by enzyme activity and protein level [2]. Feeding 1% Orotic acid with diet decreased the phosphorylation of AMPK and increased the maturation of SREBP-1 and the expression of SREBP-responsive genes in the rat liver. Orotic acid-induced lipid accumulation was also completely inhibited by rapamycin. Mouse hepatocytes and mice were resistant to Orotic acid-induced lipogenesis because of little if any response in AMPK and downstream effectors [3]. |
Synonyms | Vitamin B13, 6-Carboxyuracil |
Molecular Weight | 156.1 |
Formula | C5H4N2O4 |
CAS No. | 65-86-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (352.34 mM)
You can also refer to dose conversion for different animals. More
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Orotic acid 65-86-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair Metabolism Endogenous Metabolite Dehydrogenase Nucleoside Antimetabolite/Analog inhibit Inhibitor pyrimidine nucleotides Vitamin B-13 RNA hepatomegaly Vitamin B13 steatosis 6-Carboxyuracil Vitamin B 13 urea hepatic inhibitor