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PAT-1251

PAT-1251 is an inhibitor of LOXL2 with IC50s of 10, 0.12, and 0.16 μM for the mouse, rat, and dog and can be used in studies about fibrotic diseases.

Catalog No. T12371LCas No. 2007885-39-2

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Purity:99.78%

ee:100%

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COA CSFC LCMS HPLC FNMR HNMR

PAT-1251

Catalog No. T12371LCas No. 2007885-39-2

PAT-1251 is an inhibitor of LOXL2 with IC50s of 10, 0.12, and 0.16 μM for the mouse, rat, and dog and can be used in studies about fibrotic diseases.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$197	In Stock
5 mg	$497	In Stock
10 mg	$723	In Stock
25 mg	$1,130	In Stock
50 mg	$1,520	In Stock
100 mg	$1,980	In Stock
500 mg	$3,970	In Stock
1 mL x 10 mM (in DMSO)	$547	In Stock

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Product Introduction

Bioactivity

Description	PAT-1251 is an inhibitor of LOXL2 with IC50s of 10, 0.12, and 0.16 μM for the mouse, rat, and dog and can be used in studies about fibrotic diseases.
Targets&IC50	LOXL2 (dog):0.16 μM, LOXL2 (rat):0.12 μM, LOXL3 (human):1.17 μM, LOXL2 (mouse):0.10 μM, LOXL2 (human):0.71 μM
In vitro	PAT-1251 inhibits hLOXL2 and hLOXL3 with IC50s of 0.71 and 1.17 μM. PAT-1251 shows highly selective for LOXL2 over other amine oxidases, such as SSAO, DAO, MAO-A, and MAO-B with <10% inhibition at 10 μM[1].

Chemical Properties

Molecular Weight	399.34
Formula	C₁₈H₁₇F₄N₃O₃
Cas No.	2007885-39-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 117.0 mg/mL (293.0 mM)

H2O: 90.0 mg/mL (225.4 mM)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5041 mL	12.5207 mL	25.0413 mL	125.2066 mL
5 mM	0.5008 mL	2.5041 mL	5.0083 mL	25.0413 mL
10 mM	0.2504 mL	1.2521 mL	2.5041 mL	12.5207 mL
20 mM	0.1252 mL	0.6260 mL	1.2521 mL	6.2603 mL
50 mM	0.0501 mL	0.2504 mL	0.5008 mL	2.5041 mL
100 mM	0.0250 mL	0.1252 mL	0.2504 mL	1.2521 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc