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PD 151746

Catalog No. T2493   CAS 179461-52-0

PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2].

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PD 151746 Chemical Structure
PD 151746, CAS 179461-52-0
Pack Size Availability Price/USD Quantity
5 mg In stock $ 59.00
10 mg In stock $ 98.00
25 mg In stock $ 198.00
50 mg In stock $ 317.00
1 mL * 10 mM (in DMSO) In stock $ 66.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2].
Targets&IC50 m-calpain:5.33 μM, μ-Calpain:260 nM
Molecular Weight 237.25
Formula C11H8FNO2S
CAS No. 179461-52-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 44 mg/mL (185.5 mM)

Ethanol: 44 mg/mL (185.5 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

TargetMolReferences and Literature

1. Wang KK, et al. Proc Natl Acad Sci U S A. 1996, 93(13), 6687-6692. 2. Pörn-Ares MI, et al. Biochem J. 2003 Sep 1;374(Pt 2):403-11.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Metabolism Disease Compound Library Protease Inhibitor Library Inhibitor Library Covalent Inhibitor Library Fluorochemical Library Ubiquitination Compound Library Anti-Aging Compound Library HIF-1 Signaling Pathway Compound Library NO PAINS Compound Library

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Keywords

PD 151746 179461-52-0 Proteases/Proteasome Ubiquitination Cysteine Protease Proteasome PD-151746 PD151746 inhibitor inhibit

 

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