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PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $40 | In Stock | |
5 mg | $63 | In Stock | |
10 mg | $90 | In Stock | |
25 mg | $196 | In Stock | |
50 mg | $339 | In Stock | |
100 mg | $374 | In Stock | |
1 mL x 10 mM (in DMSO) | $68 | In Stock |
Description | PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM). |
Targets&IC50 | EP2 receptor:16 nM |
Alias | PF04418948, PF 04418948 |
Molecular Weight | 409.41 |
Formula | C23H20FNO5 |
Cas No. | 1078166-57-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (109.91 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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