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By Target- Prostaglandin Receptor
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Results for "
pf-04418948
" in TargetMol Product Catalog- Inhibitors & Agonists1
PF-04418948
Cited
PF 04418948,PF04418948
T33061078166-57-0
PF-04418948 is a potent EP2 receptor antagonist (IC50 = 16 nM for human EP2 receptors). Displays over 2000-fold selectivity for EP2 receptors over EP1, EP3, EP4, DP1 amd CRTH2 receptors; exhibits <30% binding at a diverse panel of GPCRs and ion channels at a concentration of 10 μM. Inhibits PGE2-induced increases in intracellular cAMP; reverses PGE2-invoked relaxation of mouse trachea (IC50 = 2.7 nM).
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