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PF-05221304

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Purity:99.19%

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COA HNMR HPLC

PF-05221304

Catalog No. T9209Cas No. 1370448-25-1

PF-05221304 (NSC-170984) is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis.

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Pack Size	Price	Availability
1 mg	$143	In Stock
5 mg	$293	In Stock
10 mg	$441	In Stock
25 mg	$767	In Stock
50 mg	$996	In Stock
100 mg	$1,450	In Stock
200 mg	$1,950	In Stock
500 mg	$2,890	In Stock
1 mL x 10 mM (in DMSO)	$447	In Stock

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Product Introduction

Bioactivity

Description	PF-05221304 (NSC-170984) is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis.
In vitro	PF-05221304 blocked polarization of human T cells to proinflammatory but not anti-inflammatory T cells, and suppressed activation of primary human stellate cells to myofibroblasts in vitro, showing direct effects on inflammation and fibrogenesis[1].
In vivo	PF-05221304 reduced markers of inflammation and fibrosis in the diethylnitrosamine chemical-induced liver injury model and the choline-deficient, high-fat-fed rat model[1].
Alias	STAT5 Inhibitor III, NSC 170984, R 6238,, Clesacostat

Chemical Properties

Molecular Weight	502.56
Formula	C28H30N4O5
Cas No.	1370448-25-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

5% DMSO+95% Saline: 4.75 mg/mL (9.45 mM, precipitation)

ethanol: 5mg/ml(9.95mM)

DMSO: 95mg/ml(189.03mM)

Solution Preparation Table

DMSO/5% DMSO+95% Saline

	1mg	5mg	10mg	50mg
1 mM	1.9898 mL	9.9491 mL	19.8981 mL	99.4906 mL
5 mM	0.3980 mL	1.9898 mL	3.9796 mL	19.8981 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.1990 mL	0.9949 mL	1.9898 mL	9.9491 mL
20 mM	0.0995 mL	0.4975 mL	0.9949 mL	4.9745 mL
50 mM	0.0398 mL	0.1990 mL	0.3980 mL	1.9898 mL
100 mM	0.0199 mL	0.0995 mL	0.1990 mL	0.9949 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc