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PF-05221304

Catalog No. T9209 CAS 1370448-25-1

Synonyms: NSC 170984, Clesacostat, R 6238,, STAT5 Inhibitor III

PF-05221304 is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis.

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PF-05221304, CAS 1370448-25-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PF-05221304 is an orally active, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), a rate-limiting enzymes for fatty acid synthesis.
In vitro	PF-05221304 blocked polarization of human T cells to proinflammatory but not anti-inflammatory T cells, and suppressed activation of primary human stellate cells to myofibroblasts in vitro, showing direct effects on inflammation and fibrogenesis[1].
In vivo	PF-05221304 reduced markers of inflammation and fibrosis in the diethylnitrosamine chemical-induced liver injury model and the choline-deficient, high-fat-fed rat model[1].

Synonyms	NSC 170984, Clesacostat, R 6238,, STAT5 Inhibitor III
Molecular Weight	502.571
Formula	C28H30N4O5
CAS No.	1370448-25-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 95mg/ml(189.03mM)

ethanol: 5mg/ml(9.95mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ross T T , Crowley C , Kelly K L , et al. Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems[J]. Cellular and Molecular Gastroenterology and Hepatology, 2020, 10(4).

Related Products

Related compounds with same targets

ND-646 PF-05221304 Firsocostat PF-05175157 Haloxyfop TOFA CP-640186 hydrochloride Olumacostat Glasaretil

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

PF-05221304 1370448-25-1 代谢 Acetyl-CoA Carboxylase STAT5 Inhibitor III R 6238, PF 05221304 PF05221304 Clesacostat NSC 170984 Inhibitor inhibitor inhibit

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