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Ponatinib Hydrochloride

Catalog No. T2372L   CAS 1114544-31-8
Synonyms: AP 24534, AP-24534 Hydrochloride, AP-24534, Ponatinib hydrochloride, AP24534 Hydrochloride, AP24534

Ponatinib Hydrochloride (AP-24534 Hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Ponatinib Hydrochloride Chemical Structure
Ponatinib Hydrochloride, CAS 1114544-31-8
Pack Size Availability Price/USD Quantity
10 mg In stock $ 39.00
25 mg In stock $ 72.00
50 mg In stock $ 113.00
100 mg In stock $ 172.00
200 mg In stock $ 255.00
500 mg In stock $ 433.00
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Purity: 100%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ponatinib Hydrochloride (AP-24534 Hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.
Synonyms AP 24534, AP-24534 Hydrochloride, AP-24534, Ponatinib hydrochloride, AP24534 Hydrochloride, AP24534
Molecular Weight 569.02
Formula C29H28ClF3N6O
CAS No. 1114544-31-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 22.5mg/mL (39.5mM), ultrasonic and warming and heat to 60°C)

TargetMolReferences and Literature

1. O'Hare T, et al. AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell, 2009, 16(5), 401-412. 2. Dessilly G, Panin N, Elens L, Haufroid V, Demoulin JB. Impact of ABCB1 1236C > T-2677G > T-3435C > T polymorphisms on the anti-proliferative activity of imatinib, nilotinib, dasatinib and ponatinib. Sci Rep. 2016 Jul 12;6:29559. doi: 10.1038/srep29559. PubMed PMID: 27405085; PubMed Central PMCID: PMC4941718. 3. Abid MB, De Mel S. Does ponatinib cross the blood-brain barrier? Br J Haematol. 2016 Jun 28. doi: 10.1111/bjh.14222. [Epub ahead of print] PubMed PMID: 27352067. 4. Breccia M, Abruzzese E, Iurlo A, Gozzini A, Isidori A, Gangemi D, Pregno P, Alimena G. Efficacy and safety of second-line ponatinib after failure of a single previous tyrosine kinase inhibitor for chronic myeloid leukemia patients in chronic phase. Haematologica. 2016 Jun;101(6):e267-8. doi: 10.3324/haematol.2016.145623. Epub 2016 May 31. PubMed PMID: 27252515.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Tyrosine Kinase Inhibitor Library Anti-Cancer Active Compound Library Inhibitor Library Clinical Compound Library Anti-Cancer Metabolism Compound Library Anti-Lung Cancer Compound Library Bioactive Compounds Library Max Anti-Cardiovascular Disease Compound Library

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Keywords

Ponatinib Hydrochloride 1114544-31-8 Angiogenesis Tyrosine Kinase/Adaptors FGFR VEGFR PDGFR Src AP 24534 AP 24534 Hydrochloride AP-24534 Hydrochloride AP-24534 Ponatinib hydrochloride AP24534 Hydrochloride AP24534 inhibitor inhibit

 

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