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Prostaglandin E2

Catalog No. T5014Cas No. 363-24-6
Alias Prostaglandin E2 (PGE2), PGE2, Dinoprostone

Prostaglandin E2 (PGE2) is a naturally occurring hormone involved in various physiological processes, such as smooth muscle contraction and relaxation, vasodilation and constriction, blood pressure regulation, and inflammatory regulation.

Prostaglandin E2

Prostaglandin E2

Purity: 99.95%
Catalog No. T5014Alias Prostaglandin E2 (PGE2), PGE2, DinoprostoneCas No. 363-24-6
Prostaglandin E2 (PGE2) is a naturally occurring hormone involved in various physiological processes, such as smooth muscle contraction and relaxation, vasodilation and constriction, blood pressure regulation, and inflammatory regulation.
Pack SizePriceAvailabilityQuantity
1 mg$35In Stock
2 mg$48In Stock
5 mg$68In Stock
10 mg$94In Stock
25 mg$197In Stock
50 mg$379In Stock
100 mg$589In Stock
500 mg$1,280In Stock
1 g$1,720In Stock
1 mL x 10 mM (in DMSO)$53In Stock
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Purity:99.95%
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Product Introduction

Bioactivity
Description
Prostaglandin E2 (PGE2) is a naturally occurring hormone involved in various physiological processes, such as smooth muscle contraction and relaxation, vasodilation and constriction, blood pressure regulation, and inflammatory regulation.
In vitro
METHODS: Human colorectal cancer cells LS-174T were treated with Prostaglandin E2 (0.05-10 μM) for 1-60 min, and the expression levels of target proteins were detected by Western Blot.
RESULTS: Prostaglandin E2 induced phosphorylation of Akt as early as 1 min after stimulation, and the activation of Akt reached a maximum within 10 min and persisted until 60 min. The addition of Prostaglandin E2 activated Akt in a dose-dependent manner. [1]
METHODS: FDC-like cells were treated with Prostaglandin E2 (1 μM) for 15-120 min, and the expression levels of target proteins were detected by Western Blot.
RESULTS: Prostaglandin E2 did not increase p-ERK, but decreased p-ERK at 60 and 120 min. on the contrary, p-p38 increased starting at 15 min and continued to 60 min. [2]
In vivo
METHODS: To test the role of EP2 receptors in the in vivo absorption response, Prostaglandin E2 (3 mg/kg) was injected subcutaneously four times daily for three days into EP2+/+ and EP2-/- mice on a 129/SvEv background.
RESULTS: Prostaglandin E2 increased serum calcium from 9.8+/-0.5 to 10.7+/-0.3 mg/dL in EP2+/+ mice but not in EP2-/- mice. [3]
METHODS: To study the effects on bone, Prostaglandin E2 (6 mg/kg) was injected subcutaneously into C57BL/6 mice once daily for 3-12 days.
RESULTS: Prostaglandin E2-treated mice showed a decrease in trabecular bone volume (BV/TV) at 14 days, indicating increased bone resorption. However, the Prostaglandin E2-treated 3-day group also stimulated bone formation at 14 days due to increased mineral deposition rate (MAR) and bone formation rate (BFR/BS). [4]
AliasProstaglandin E2 (PGE2), PGE2, Dinoprostone
Chemical Properties
Molecular Weight352.47
FormulaC20H32O5
Cas No.363-24-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (141.86 mM)
5% DMSO+95% Saline: 1.5 mg/mL (4.26 mM), Please add co-solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
Solution Preparation Table
5% DMSO+95% Saline/DMSO
1mg5mg10mg50mg
1 mM2.8371 mL14.1856 mL28.3712 mL141.8560 mL
DMSO
1mg5mg10mg50mg
5 mM0.5674 mL2.8371 mL5.6742 mL28.3712 mL
10 mM0.2837 mL1.4186 mL2.8371 mL14.1856 mL
20 mM0.1419 mL0.7093 mL1.4186 mL7.0928 mL
50 mM0.0567 mL0.2837 mL0.5674 mL2.8371 mL
100 mM0.0284 mL0.1419 mL0.2837 mL1.4186 mL

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