Shopping Cart

Remove All

Your shopping cart is currently empty

Pyridostatin TFA

Select Batch

Resource Download

COA HPLC HNMR

Pyridostatin TFA

Catalog No. T4470Cas No. 1472611-44-1

Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$33	In Stock
5 mg	$74	In Stock
10 mg	$113	In Stock
25 mg	$201	In Stock
50 mg	$305	In Stock
100 mg	$497	In Stock
1 mL x 10 mM (in DMSO)	$128	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "Pyridostatin TFA"

Product Introduction

Bioactivity

Description	Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.
In vitro	Pyridostatin decreases the proliferation of MRC-5–SV40 cells and various cancer cell lines, and induces cell-cycle arrest by DNA-damage checkpoint activation. Pyridostatin also reduces SRC-dependent cell motility in MDA-MB-231 cells by interacting with G-quadruplex motifs in SRC.Pyridostatin decreases EBNA1 synthesis via inhibition of G-quadruplexes.
Cell Research	Cell lines: MRC-5–SV40 cells and various cancer cell linesConcentrations: 10 μMIncubation Time: 48 hMethod: Cells are plated at equal confluence and are left either untreated or were treated with 2 μM pyridostatin continually during the indicated time before harvesting the cells. Cells from individual plates are trypsinized and counted in a Coulter counter. Graphs represent the total cell numbers at each time interval, and the error bars represent the s.e.m. Data represent three independent experiments.

Chemical Properties

Molecular Weight	938.71
Formula	C37H35F9N8O11
Cas No.	1472611-44-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (95.88 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0653 mL	5.3265 mL	10.6529 mL	53.2646 mL
5 mM	0.2131 mL	1.0653 mL	2.1306 mL	10.6529 mL
10 mM	0.1065 mL	0.5326 mL	1.0653 mL	5.3265 mL
20 mM	0.0533 mL	0.2663 mL	0.5326 mL	2.6632 mL
50 mM	0.0213 mL	0.1065 mL	0.2131 mL	1.0653 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc