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Pyridostatin TFA

Catalog No. T4470   CAS 1472611-44-1

Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.

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Pyridostatin TFA Chemical Structure
Pyridostatin TFA, CAS 1472611-44-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 35.00
2 mg In stock $ 47.00
5 mg In stock $ 74.00
10 mg In stock $ 113.00
25 mg In stock $ 201.00
50 mg In stock $ 305.00
100 mg In stock $ 513.00
1 mL * 10 mM (in DMSO) In stock $ 117.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2.
Targets&IC50 G-quadruplexe(Cell-free assay):490 nM(Kd)
In vitro Pyridostatin decreases the proliferation of MRC-5–SV40 cells and various cancer cell lines, and induces cell-cycle arrest by DNA-damage checkpoint activation. Pyridostatin also reduces SRC-dependent cell motility in MDA-MB-231 cells by interacting with G-quadruplex motifs in SRC.Pyridostatin decreases EBNA1 synthesis via inhibition of G-quadruplexes.
Cell Research Cell lines: MRC-5–SV40 cells and various cancer cell linesConcentrations: 10 μMIncubation Time: 48 hMethod: Cells are plated at equal confluence and are left either untreated or were treated with 2 μM pyridostatin continually during the indicated time before harvesting the cells. Cells from individual plates are trypsinized and counted in a Coulter counter. Graphs represent the total cell numbers at each time interval, and the error bars represent the s.e.m. Data represent three independent experiments.
Molecular Weight 938.71
Formula C37H35F9N8O11
CAS No. 1472611-44-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90 mg/mL (95.88 mM)

TargetMolReferences and Literature

1. Koirala D,etal.A single-molecule platform for investigation of interactions between G-quadruplexes and small-molecule ligands.Nat Chem. 2011 Aug 28;3(10):782-7. 2. Rodriguez R,etal. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes.Nat Chem Biol. 2012 Feb 5;8(3):301-10. 3. Murat P,etal.G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation.Nat Chem Biol. 2014 May;10(5):358-64.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Bioactive Compounds Library Max NO PAINS Compound Library Bioactive Compound Library DNA Damage & Repair Compound Library Anti-Aging Compound Library Anti-Cancer Compound Library Cell Cycle Compound Library

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Keywords

Pyridostatin TFA 1472611-44-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis RR82 neurodegeneration G-quadruplex SRC inhibit arrest damage cycle DSB Pyridostatin RR-82 Inhibitor RR 82 DNA structure inhibitor

 

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