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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $41 | In Stock | |
5 mg | $67 | In Stock | |
10 mg | $98 | In Stock | |
25 mg | $170 | In Stock | |
50 mg | $277 | In Stock | |
100 mg | $457 | In Stock | |
1 mL x 10 mM (in DMSO) | $71 | In Stock |
Description | RAD51 Inhibitor B02 (B02) (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM. |
In vitro | RAD51 Inhibitor B02 specifically inhibits human RAD51 (IC50=27.4 μM), but not its E. coli homologue RecA (IC50>250 μM).The combination of B02 with cisplatin has the strongest killing effect on the human breast cancer cells MDA-MB-231. |
In vivo | B02 substantially improves the therapeutic efficacy of cisplatin against tumor cells in vivo, demonstrating tolerability in mice at dosages up to 50 mg/kg without significant body weight reduction. Mice treated solely with B02 exhibited no tumor growth inhibition; however, those administered 4 mg/kg of cisplatin experienced a 33% reduction in tumor growth. Crucially, a combination treatment involving 50 mg/kg B02 and 4 mg/kg cisplatin resulted in a 66% decrease in tumor size[2]. |
Alias | B02 |
Molecular Weight | 339.39 |
Formula | C22H17N3O |
Cas No. | 1290541-46-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 33.9 mg/mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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