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Remdesivir

Catalog No. T7766 CAS 1809249-37-3

Synonyms: DNA/RNA Synthesis, Remdesivir, GS 5734, COVID-19, MERS-CoV, 2019-nCoV, antiviral, SARS coronavirus, Inhibitor, GS5734, SARS-CoV, GS-5734, inhibit, infection

Remdesivir is a nucleoside analogue, with effective antiviral activity( EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells)

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Remdesivir, CAS 1809249-37-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Remdesivir is a nucleoside analogue, with effective antiviral activity( EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells)
Targets&IC50	MERS-CoV:74 nM (EC50), SARS-CoV:74 nM (EC50)
In vitro	GS-5734 inhibits murine hepatitis virus (MHV) with similar 50% effective concentration values (EC50) as SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV).?Passage of WT MHV in the presence of the GS-5734 parent nucleoside selected two mutations in the nsp12 polymerase at residues conserved across all CoVs that conferred up to 5.6-fold resistance to GS-5734, as determined by EC50[1].

Synonyms	DNA/RNA Synthesis, Remdesivir, GS 5734, COVID-19, MERS-CoV, 2019-nCoV, antiviral, SARS coronavirus, Inhibitor, GS5734, SARS-CoV, GS-5734, inhibit, infection
Molecular Weight	602.585
Formula	C27H35N6O8P
CAS No.	1809249-37-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (207.44 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Williams C G, Jureka A S, Silvas J A, et al. Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication. Cell Reports. 2021: 109479. 1. Agostini M L , Andres E L , Sims A C , et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease[J]. Mbio, 2018, 9(2):e00221-18. 2. Li, Quanjie, et al Corilagin inhibits SARS-CoV-2 replication by targeting viral RNA-dependent RNA polymerase.. Acta Pharmaceutica Sinica B. (2021). 2. Wang M , Cao R , Zhang L , et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro[J]. cell research. 3. Silvas J A, Jureka A S, Nicolini A M, et al. Inhibitors of VPS34 and lipid metabolism suppress SARS-CoV-2 replication[J]. bioRxiv. 2020. 3. Li Y, Cao L, Li G, et al. Remdesivir Metabolite GS-441524 Efficiently Inhibits SARS-CoV-2 Infection in Mouse Model. Journal of Medicinal Chemistry. 2020 4. Zhao J, Liu Q, Yi D, et al. 5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis. Antiviral Research. 2022: 105254. 4. Nguyenla X, Wehri E, Van Dis E, et al. Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells[J]. bioRxiv. 2020 5. Li Y, Cao L, Li G, et al. Remdesivir Metabolite GS-441524 Efficiently Inhibits SARS-CoV-2 Infection in Mouse Model[J] . Journal of medicinal chemistry. 2020 5. Zhao J, Liu Q, Yi D, et al. 5-Iodotubercidin inhibits SARS-CoV-2 RNA synthesis. Antiviral Research. 2022: 105254. 6. Nicholson M W, Huang C Y, Wang J Y, et al. Cardio-and Neurotoxicity of Selected Anti-COVID-19 Drugs. Pharmaceuticals. 2022, 15(6): 765 7. Nguyenla X, Wehri E, Van Dis E, et al. Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells. Scientific Reports. 2022 Nov 2;12(1):18506.

Related compound libraries

This product is contained In the following compound libraries：

DNA Damage & Repair Compound Library Drug Repurposing Compound Library FDA-Approved Drug Library Anti-COVID-19 Compound Library Anti-Viral Compound Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compound Library Clinical Compound Library

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