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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $122 | In Stock | |
5 mg | $339 | In Stock | |
10 mg | $537 | In Stock | |
25 mg | $797 | In Stock | |
50 mg | $1,120 | In Stock | |
100 mg | $1,510 | In Stock | |
200 mg | $1,990 | In Stock | |
1 mL x 10 mM (in DMSO) | $450 | In Stock |
Description | Remdesivir (GS-5734) is a nucleoside analog, a broad-spectrum antiviral compound that exerts its activity by inhibiting the RNA-dependent RNA polymerase of viruses. Remdesivir is active against Ebola, SARS, and MERS viruses, and is potentially therapeutic against COVID-19. |
In vitro | METHODS: Mouse hepatitis virus (MHV)-infected DBT cells were incubated with Remdesivir (0.01-1 µM) for 24 h, and the supernatant was analyzed for viral titer by plaque assay. RESULTS: Remdesivir effectively inhibited MHV with an EC50 of 0.03 µM. [1] METHODS: 2019-nCoV-infected Vero E6 cells were treated with Remdesivir (0-400 µM) for 48 h. Viral yield in cell supernatants was detected using qRT-PCR. RESULTS: Remdesivir effectively blocked viral infection at low micromolar concentrations and showed high SI (EC50 = 0.77 μM; CC50 > 100 μM; SI > 129.87). [2] |
In vivo | METHODS: To assay antiviral activity in vivo, Remdesivir (25 mg/kg, 12% sulfobutylether-β-cyclodextrin sodium salt in water (with HCl/NaOH) at pH 5.0) was injected subcutaneously into MERS-CoV-infected Ces1c-/- hDPP4 mice twice daily. RESULTS: Prophylactic Remdesivir reduced MERS-CoV replication and disease. [3] METHODS: To assay antiviral activity in vivo, Remdesivir (25 mg/kg once daily, administered three times) and Loratadine (10 mg/kg once daily, administered four times) were administered intraperitoneally to 501Y.V2 SARS-CoV-2 infected BALB/c mice. RESULTS: The combination of Remdesivir and the antihistamine Loratadine reduced SARS-CoV-2 replication and inflammation and protected against lung injury. [4] |
Alias | GS-5734 |
Molecular Weight | 602.58 |
Formula | C27H35N6O8P |
Cas No. | 1809249-37-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (82.98 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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