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Remodelin

Catalog No. T3499 CAS 949912-58-7

Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.

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Remodelin, CAS 949912-58-7

Pack Size	Availability	Price/USD
5 mg	In stock	$ 50.00
10 mg	In stock	$ 70.00
25 mg	In stock	$ 132.00
50 mg	In stock	$ 195.00
100 mg	In stock	$ 288.00
200 mg	In stock	$ 433.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 99.78%

Purity: 99.39%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Remodelin is an effective and specific inhibitor of the acetyl-transferase protein NAT10.

Kinase Assay

GRK5 and urea-washed bovine rod outer segments (ROS) are mixed in the dark in buffer containing 20 mM HEPES, pH 7.5, 4 mM MgCl2, and 2 mM EDTA and incubated for 35 min at room temperature. The reaction mixtures are exposed to ambient fluorescent light for 1 min prior to initiation of the reaction by addition of ATP (with [γ-32P]ATP) to a final concentration of 1 mM. Final concentration of GRK5 is 100 nM and ROS is between 0.75 and 24 μM. Reactions are initiated at room temperature, and samples are taken at 2-5 min and then quenched with SDS-PAGE loading dye. Proteins are separated using SDS-PAGE, gel is dried, and the incorporation of γ-32P is detected using a phosphor storage screen. Rates at 0 min are plotted against the ROS concentration, and Vmax and Kmvalues are determined using the Michaelis-Menten equation. Vmax of each curve is normalized to the Vmax of GRK5561 run in parallel. Melting point determinations in response to 200 μM CCG215022 are performed in 20 mM HEPES, pH 7.0, 5 mM MgCl2, 2 mM DTT, 1 mM CHAPS at a final GRK5 concentration of 0.2 mg/mL and 100 μM anilinonaphthalene-8-sulfonic acid using a ThermoFluor plate reader. Melting points of GRK5 variants are assayed in a buffer containing 20 mM HEPES, pH 8.0, 200 mM NaCl, 2 mM DTT, 2.5 mM MgCl2, and 0.1 mM anilinonaphthalene-8-sulfonic acid with or without 5 mM ATP. Final GRK5 concentration for these assays is 0.1 mg/mL[1].

Molecular Weight	282.36
Formula	C15H14N4S
CAS No.	949912-58-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (88.54 mM)

References and Literature

1. Larrieu D, et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science. 2014 May 2;344(6183):527-32.

Citations

1. Wang X, Li K, Cheng M, et al.RNPS1 stabilizes NAT10 protein to facilitate translation in cancer via tRNA ac4C modification.bioRxiv.2023: 2023.02. 11.528122. 2. Dang Y, Li J, Li Y, et al.N-acetyltransferase 10 regulates alphavirus replication via N4-acetylcytidine (ac4C) modiﬁcation of the lymphocyte antigen six family member E (LY6E) mRNA.Journal of Virology.2024: e01350-23.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Chromatin Modification Compound Library Epigenetics Compound Library Bioactive Compounds Library Max Stem Cell Differentiation Compound Library Anti-Hypertension Compound Library Histone Modification Compound Library NO PAINS Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

L002 JG-2016 CPI-637 NSC 228155 MOZ-IN-2 MG 149 A-485 NU 9056

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Remodelin 949912-58-7 Chromatin/Epigenetic Histone Acetyltransferase HAT inhibit Inhibitor HATs inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.